锌指蛋白与消化系统肿瘤

doi:10.3760/cma.j.issn.1673-422X.2020.02.011

国际肿瘤学杂志 ›› 2020, Vol. 47 ›› Issue (2): 115-118.doi: 10.3760/cma.j.issn.1673-422X.2020.02.011

锌指蛋白与消化系统肿瘤

田春方, 沙丹()

山东第一医科大学附属省立医院化疗科,济南 250021

收稿日期:2019-10-28 修回日期:2019-11-18 出版日期:2020-02-08 发布日期:2020-05-27
通讯作者: 沙丹 E-mail:shadanslyy@126.com
基金资助:
山东省自然科学基金(ZR2013HQ027)

Zinc finger proteins and digestive system cancers

Tian Chunfang, Sha Dan()

Department of Chemotherapy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China

Received:2019-10-28 Revised:2019-11-18 Online:2020-02-08 Published:2020-05-27
Contact: Sha Dan E-mail:shadanslyy@126.com
Supported by:
Natural Science Foundation of Shandong Province of China(ZR2013HQ027)

摘要/Abstract

摘要：

锌指蛋白是人类基因组中最大的转录家族,通过促癌或抑癌作用广泛参与消化系统肿瘤的发生发展过程。研究表明多种锌指蛋白的表达异常与胃癌、肝癌、结直肠癌和胰腺癌患者的临床病理特征及预后密切相关。研究锌指蛋白的作用机制有助于为临床治疗消化系统肿瘤提供新的靶点。

关键词: 胃肿瘤, 癌,肝细胞, 结直肠肿瘤, 胰腺肿瘤, 锌指蛋白

Abstract:

Zinc finger proteins (ZNFs) belong to the largest transcriptional factor family in human genome. ZNFs are widely involved in the development and progression of digestive system cancers by promoting or inhibiting carcinogenesis. Studies have shown that the abnormal expressions of various ZNFs are closely related to the clinicopathologic features and prognosis of patients with digestive system cancers, including gastric cancer, liver cancer, colorectal cancer and pancreatic cancer. Exploring the underlying mechanism of ZNFs will help to provide new targets for clinical treatment of digestive system cancers.

Key words: Stomach neoplasms, Carcinoma, hepatocellular, Colorectal neoplasms, Pancreatic neoplasms, Zinc finger proteins

田春方, 沙丹. 锌指蛋白与消化系统肿瘤[J]. 国际肿瘤学杂志, 2020, 47(2): 115-118.

Tian Chunfang, Sha Dan. Zinc finger proteins and digestive system cancers[J]. Journal of International Oncology, 2020, 47(2): 115-118.

参考文献 31

[1]	Bray F, Ferlay J, Soerjomataram I , et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018,68(6):394-424. DOI: 10.3322/caac.21492. doi: 10.3322/caac.v68.6
[2]	Feng RM, Zong YN, Cao SM , et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?[J]. Cancer Commun (Lond), 2019,39(1):22. DOI: 10.1186/s40880-019-0368-6.
[3]	Frankel AD, Pabo CO . Fingering too many proteins[J]. Cell, 1988,53(5):675. DOI: 10.1016/0092-8674(88)90083-9. doi: 10.1016/0092-8674(88)90083-9
[4]	Braschi B, Denny P, Gray K , et al. Genenames.org: the HGNC and VGNC resources in 2019[J]. Nucleic Acids Res, 2019,47(D1):D786-D792. DOI: 10.1093/nar/gky930. doi: 10.1093/nar/gky930
[5]	Cassandri M, Smirnov A, Novelli F , et al. Zinc-finger proteins in health and disease[J]. Cell Death Discov, 2017,3:17071. DOI: 10.1038/cddiscovery.2017.71. doi: 10.1038/cddiscovery.2017.71
[6]	Eom KS, Cheong JS, Lee SJ . Structural analyses of Zinc finger domains for specific interactions with DNA[J]. J Microbiol Biotechnol, 2016,26(12):2019-2029. DOI: 10.4014/jmb.1609.09021. doi: 10.4014/jmb.1609.09021
[7]	Schmitges FW, Radovani E, Najafabadi HS , et al. Multiparameter functional diversity of human C2H2 zinc finger proteins[J]. Genome Res, 2016,26(12):1742-1752. DOI: 10.1101/gr.209643.116.
[8]	Jen J, Wang YC . Zinc finger proteins in cancer progression[J]. J Biomed Sci, 2016,23(1):53. DOI: 10.1186/s12929-016-0269-9.
[9]	Liao Z, Wang X, Chen X , et al. Prediction and identification of Kruppel-like transcription factors by machine learning method[J]. Comb Chem High Throughput Screen, 2017,20(7):594-602. DOI: 10.2174/1386207320666170314094951.
[10]	Zhu M, Zhang N, Lu X , et al. Negative regulation of Kruppel-like factor 4 on microRNA-106a at upstream transcriptional level and the role in gastric cancer metastasis[J]. Dig Dis Sci, 2018,63(10):2604-2616. DOI: 10.1007/s10620-018-5143-z.
[11]	Hashimoto I, Nagata T, Sekine S , et al. Prognostic significance of KLF4 expression in gastric cancer[J]. Oncol Lett, 2017,13(2):819-826. DOI: 10.3892/ol.2016.5499.
[12]	Zhou T, Chen S, Mao X . miR-145-5p affects the differentiation of gastric cancer by targeting KLF5 directly[J]. J Cell Physiol, 2019,234(5):7634-7644. DOI: 10.1002/jcp.27525.
[13]	Tan B, Li Y, Zhao Q , et al. ZNF139 increases multidrug resistance in gastric cancer cells by inhibiting miR-185[J]. Biosci Rep, 2018, 38(5): pii: BSR20181023. DOI: 10.1042/BSR20181023.
[14]	Nie H, Mu J, Wang J , et al. miR1955p regulates multidrug resistance of gastric cancer cells via targeting ZNF139[J]. Oncol Rep, 2018,40(3):1370-1378. DOI: 10.3892/or.2018.6524.
[15]	Cao L, Wang S, Zhang Y , et al. Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A[J]. Oncogene, 2018,37(26):3601-3616. DOI: 10.1038/s41388-018-0220-5.
[16]	Chockley PJ, Keshamouni VG . Immunological consequences of epithelial-mesenchymal transition in tumor progression[J]. J Immunol, 2016,197(3):691-698. DOI: 10.4049/jimmunol.1600458.
[17]	Wang X, Hou Q, Zhou X . LAMA4 expression is activated by zinc finger E-box-binding homeobox 1 and independently predicts poor overall survival in gastric cancer[J]. Oncol Rep, 2018,40(3):1725-1733. DOI: 10.3892/or.2018.6564.
[18]	Geng DM, Kan XM, Zhang WW . Effect of ZEB2 silencing on cisplatin resistance in gastric cancer[J]. Eur Rev Med Pharmacol Sci, 2017,21(8):1746-1752.
[19]	Chen H, Lu W, Huang C , et al. Prognostic significance of ZEB1 and ZEB2 in digestive cancers: a cohort-based analysis and secondary analysis[J]. Oncotarget, 2017,8(19):31435-31448. DOI: 10.18632/oncotarget.15634.
[20]	Li GQ, He Q, Yang L , et al. Clinical significance of myeloid Zinc finger 1 expression in the progression of gastric tumourigenesis[J]. Cell Physiol Biochem, 2017,44(3):1242-1250. DOI: 10.1159/000485454.
[21]	Hui HX, Hu ZW, Jiang C , et al. ZNF418 overexpression protects against gastric carcinoma and prompts a good prognosis[J]. Onco Targets Ther, 2018,11:2763-2770. DOI: 10.2147/OTT.S160802.
[22]	Dai C, Dong Q, Lu Q , et al. Prognostic value of Zinc-finger protein X-linked in patients with solid tumors[J]. Minerva Chir, 2017,72(1):81-88. DOI: 10.23736/S0026-4733.16.07198-4.
[23]	Wang C, Fu SY, Wang MD , et al. Zinc finger protein X-linked promotes expansion of EpCAM⁺ cancer stem-like cells in hepatocellular carcinoma[J]. Mol Oncol, 2017,11(5):455-469. DOI: 10.1002/1878-0261.12036.
[24]	Pang J, Li Z, Wang G , et al. miR-214-5p targets KLF5 and suppresses proliferation of human hepatocellular carcinoma cells[J]. J Cell Biochem, 2018. DOI: 10.1002/jcb.27498.
[25]	Guo C, Ma J, Deng G , et al. ZEB1 promotes oxaliplatin resistance through the induction of epithelial-mesenchymal transition in colon cancer cells[J]. J Cancer, 2017,8(17):3555-3566. DOI: 10.7150/jca.20952.
[26]	Li MZ, Wang JJ, Yang SB , et al. ZEB2 promotes tumor metastasis and correlates with poor prognosis of human colorectal cancer[J]. Am J Transl Res, 2017,9(6):2838-2851.
[27]	Yan X, Shan Z, Yan L , et al. High expression of Zinc-finger protein X-linked promotes tumor growth and predicts a poor outcome for stage Ⅱ/Ⅲ colorectal cancer patients[J]. Oncotarget, 2016,7(15):19680-19692. DOI: 10.18632/oncotarget.7547.
[28]	Xiang S, Xiang T, Xiao Q , et al. Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer[J]. Int J Oncol, 2017,51(3):801-811. DOI: 10.3892/ijo.2017.4064.
[29]	Xu WY, Hu QS, Qin Y , et al. Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer[J]. World J Gastroenterol, 2018,24(43):4893-4905. DOI: 10.3748/wjg.v24.i43.4893.
[30]	Song S, Yu W, Lin S , et al. LncRNA ADPGK-AS1 promotes pancreatic cancer progression through activating ZEB1-mediated epithelial-mesenchymal transition[J]. Cancer Biol Ther, 2018,19(7):573-583. DOI: 10.1080/15384047.2018.1423912.
[31]	Song X, Zhu M, Zhang F , et al. ZFX promotes proliferation and metastasis of pancreatic cancer cells via the MAPK pathway[J]. Cell Physiol Biochem, 2018,48(1):274-284. DOI: 10.1159/000491727.

锌指蛋白与消化系统肿瘤

Zinc finger proteins and digestive system cancers

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 31

相关文章 15

编辑推荐

Metrics

本文评价

[1]	袁健, 黄燕华. Hp-IgG抗体联合血清DKK1、sB7-H3对早期胃癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(6): 338-343.
[2]	张蕊, 褚衍六. 基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 370-375.
[3]	高凡, 王萍, 杜超, 褚衍六. 肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.
[4]	杨琳, 路宁, 温华, 张明鑫, 朱琳. 炎症负荷指数与胃癌临床关系研究[J]. 国际肿瘤学杂志, 2024, 51(5): 274-279.
[5]	王俊毅, 洪楷彬, 纪荣佳, 陈大朝. 癌结节对结直肠癌根治性切除术后肝转移的影响[J]. 国际肿瘤学杂志, 2024, 51(5): 280-285.
[6]	张洁, 范玲, 李杰, 温华, 苏媛媛, 路宁, 张明鑫. 原发性胰腺淋巴瘤1例并文献复习[J]. 国际肿瘤学杂志, 2024, 51(5): 316-320.
[7]	解淑萍, 孙亚红, 汪超. 早期肿瘤标志物联合NLR、PLR预测胃癌免疫治疗疗效[J]. 国际肿瘤学杂志, 2024, 51(3): 157-165.
[8]	刘玉兰, 井海燕, 孙静, 宋伟, 沙丹. 胃癌免疫治疗疗效预测及预后标志物的研究进展[J]. 国际肿瘤学杂志, 2024, 51(3): 175-180.
[9]	孙国宝, 杨倩, 庄庆春, 高斌斌, 孙晓刚, 宋伟, 沙丹. 结直肠癌肝转移组织病理学生长方式研究进展[J]. 国际肿瘤学杂志, 2024, 51(2): 114-118.
[10]	刘德宝, 孙子雯, 鲁守堂, 徐海东. ASB6在结直肠癌组织中的表达及临床意义[J]. 国际肿瘤学杂志, 2023, 50(8): 470-474.
[11]	邵慧芳, 王学红, 芦永福. CST1在胃癌进展中的作用机制及临床意义[J]. 国际肿瘤学杂志, 2023, 50(8): 489-492.
[12]	朱思雨, 王学红, 李文茜, 刘曙. 胃癌患者血清FABP1水平及其与幽门螺杆菌感染的关系[J]. 国际肿瘤学杂志, 2023, 50(6): 336-341.
[13]	杨娅, 王慧礼, 刘艳, 郭金凤, 王春霞, 吕敏, 山长平. GCSH基因在胃癌SNU-1细胞增殖和凋亡中的作用研究[J]. 国际肿瘤学杂志, 2023, 50(5): 257-262.
[14]	陈卓, 陶俊, 陈琳, 柯晶. 外周血miR-194联合粪便miR-143检测对结直肠癌临床筛查的价值[J]. 国际肿瘤学杂志, 2023, 50(5): 268-273.
[15]	全祯豪, 徐飞鹏, 黄哲, 黄先进, 陈日红, 孙开裕, 胡旭, 林琳. 沉默lncRNA FTX通过miR-22-3p/NLRP3炎症体通路抑制胃癌细胞增殖[J]. 国际肿瘤学杂志, 2023, 50(4): 202-207.