微生物群与胰腺癌

doi:10.3760/cma.j.issn.1673-422X.2020.01.009

摘要/Abstract

摘要：

在高通量测序技术的推动下,近年来研究发现特定微生物群比例的变化与胰腺癌的发生发展有关,包括口腔中的微生物、胃肠道内菌群及胰腺内菌群等,其中口腔内牙龈卟啉单胞菌与胰腺癌风险呈正相关,这可能为胰腺癌的诊断提供新的生物学标志物。微生物群与胰腺癌的多种治疗方式密切相关,肠道菌群失调可影响化疗效果,胰腺癌内的细菌可诱导免疫耐受,合并细菌感染时可导致术后并发症发生率增多。

关键词: 微生物群, 胰腺肿瘤, 治疗

Abstract:

In recent years, driven by high-throughput sequencing technology, it has been found that changes in the proportion of specific microbiota are related to the occurrence and development of pancreatic cancer, including oral microbes, gastrointestinal flora, and pancreatic flora. Porphyromonas has a positive correlation with pancreatic cancer risk, which may provide new biomarkers for the diagnosis of pancreatic cancer. In addition, the microbiota is closely related to various treatments for pancreatic cancer. When the intestinal flora is imbalanced, it will affect the effect of chemotherapy. Bacteria in pancreatic cancer can induce immune tolerance. Complications with bacterial infection can lead to postoperative complications increase.

Key words: Microbiota, Pancreatic neoplasms, Therapy

纪周新, 贺德. 微生物群与胰腺癌[J]. 国际肿瘤学杂志, 2020, 47(1): 46-50.

Ji Zhouxin, He De. Microbiota and pancreatic cancer[J]. Journal of International Oncology, 2020, 47(1): 46-50.

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