同源盒基因MEOX1在肿瘤中的研究进展

doi:10.3760/cma.j.issn.1673-422X.2019.05.005

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (5): 278-280.doi: 10.3760/cma.j.issn.1673-422X.2019.05.005

同源盒基因MEOX1在肿瘤中的研究进展

张媛，孙力超

国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室，北京100021

收稿日期:2019-04-16 出版日期:2019-05-08 发布日期:2019-06-14
通讯作者: 孙力超 E-mail:sunlichao@cicams.ac.cn
基金资助:
国家自然科学基金（81773170）；中国医学科学院医学与健康科技创新工程（2016-I2M-3-013）

Advances of homeobox gene MEOX1 in tumors

Zhang Yuan, Sun Lichao

National Cancer Center, National Clinical Research Center for Cancer; State Key Laboratory of Molecular Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Received:2019-04-16 Online:2019-05-08 Published:2019-06-14
Contact: Sun Lichao E-mail:sunlichao@cicams.ac.cn
Supported by:
National Natural Science Foundation of China (81773170); Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2016-I2M-3-013)

摘要/Abstract

摘要： 作为一种同源盒转录因子，MEOX1可通过与基因组特异DNA基序相结合调控目的基因的表达。MEOX1在细胞增殖、迁移和分化中起关键作用，并参与胚胎发育中骨骼、肌肉、血管的形成。近年来研究发现，MEOX1在乳腺癌、肺癌、卵巢癌、前列腺癌等多种肿瘤组织中高表达，并与肿瘤患者的淋巴结转移和不良预后密切相关。同时MEOX1还可调控肿瘤细胞的增殖和迁移，提示其在肿瘤的发生发展中起重要作用。

关键词: 基因, 同源盒, 肿瘤, MEOX1

Abstract: As a homeobox transcription factor, MEOX1 can regulate the target genes by binding the specific DNA sequence. MEOX1 not only plays essential roles in cell proliferation, migration and differentiation, but also participates in the formation of skeleton, muscle and blood vessel during embryonic development. Recent studies demonstrate that MEOX1 is over-expressed in breast cancer, lung cancer, ovarian cancer and prostate cancer tissues, which is closely associated with lymph node metastasis and poor prognosis in patients with cancer. Furthermore, MEOX1 can regulate the proliferation and migration of cancer cells, which suggests that it plays an important role in the occurrence and development of tumors.

Key words: Genes, homeobox, Neoplasms, MEOX1

张媛，孙力超. 同源盒基因MEOX1在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2019, 46(5): 278-280.

Zhang Yuan, Sun Lichao. Advances of homeobox gene MEOX1 in tumors[J]. Journal of International Oncology, 2019, 46(5): 278-280.

参考文献

［1］ Monterisi S, Lo Riso P, Russo K, et al. HOXB7 overexpression in lung cancer is a hallmark of acquired stemlike phenotype［J］. Oncogene, 2018, 37(26): 3575-3588. DOI: 10.1038/s41388-018-0229-9. ［2］ Hu H, Chen Y, Cheng S, et al. Dysregulated expression of homebox gene HOXA13 is correlated with the poor prognosis in bladder cancer［J］. Wien Klin Wochenschr, 2017, 129(11-12): 391397. DOI: 10.1007/s0050801611084. ［3］ Skvarova Kramarzova K, Fiser K, Mejstrikova E, et al. Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations［J］. J Hematol Oncol, 2014, 7: 94. DOI: 10.1186/s1304501400940. ［4］ Futreal PA, Cochran C, Rosenthal J, et al. Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture［J］. Hum Mol Genet, 1994, 3(8): 1359-1364. ［5］ Sawamiphak S, Stainier DY. Developmental biology: it takes muscle to make blood cells［J］. Nature, 2014, 512(7514): 257-258. DOI: 10.1038/nature13740. ［6］ Karaca E, Yuregir OO, Bozdogan ST, et al. Rare variants in the notch signaling pathway describe a novel type of autosomal recessive KlippelFeil syndrome［J］. Am J Med Genet A, 2015, 167A(11): 2795-2799. DOI: 10.1002/ajmg.a.37263. ［7］ Wu B, Zhang L, Zhu YH, et al. Mesoderm/mesenchyme homeobox gene 1 promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling［J］. Int J Cardiol, 2018, 251: 82-89. DOI: 10.1016/j.ijcard.2017.10.098. ［8］ Nguyen PD, Gurevich DB, Sonntag C, et al. Muscle stem cells undergo extensive clonal drift during tissue growth via Meox1mediated induction of G2 cellcycle arrest［J］. Cell Stem Cell, 2017, 21(1): 107-119, e6. DOI: 10.1016/j.stem.2017.06.003. ［9］ Lefebvre M, DieuxCoeslier A, Baujat G, et al. Diagnostic strategy in segmentation defect of the vertebrae: a retrospective study of 73 patients［J］. J Med Genet, 2018, 55(6): 422-429. DOI: 10.1136/jmedgenet-2017-104939. ［10］ Dauer MVP, Currie PD, Berger J. Skeletal malformations of Meox1deficient zebrafish resemble human KlippelFeil syndrome［J］. J Anat, 2018, 233(6): 687-695. DOI: 10.1111/joa.12890. ［11］ Thiaville MM, Stoeck A, Chen L, et al. Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites［J］. PLoS One, 2012, 7(5): e36054. DOI: 10.1371/journal.pone.0036054. ［12］ Chen X, Jung JG, ShajahanHaq AN, et al. ChIPBIT: bayesian inference of target genes using a novel joint probabilistic model of ChIPseq profiles［J］. Nucleic Acids Res, 2016, 44(7): e65. DOI: 10.1093/nar/gkv1491. ［13］ Wei X, Yu L, Li Y. PBX1 promotes the cell proliferation via JAK2/STAT3 signaling in clear cell renal carcinoma［J］. Biochem Biophys Res Commun, 2018, 500(3): 650-657. DOI: 10.1016/j.bbrc.2018.04.127. ［14］ Sun L, Burnett J, Gasparyan M, et al. Novel cancer stem cell targets during epithelial to mesenchymal transition in PTENdeficient trastuzumabresistant breast cancer［J］. Oncotarget, 2016, 7(32): 5140851422. DOI: 10.18632/oncotarget.9839. ［15］ Peng C, Lou HL, Liu F, et al. Enhanced identification of potential pleiotropic genetic variants for bone mineral density and breast cancer［J］. Calcif Tissue Int, 2017, 101(5): 489-500. DOI: 10.1007/s00223-017-0308-x. ［16］ Sun L, Yuan H, Burnett J, et al. MEOX1 promotes tumor progression and predicts poor prognosis in human nonsmallcell lung cancer［J］. Int J Med Sci, 2019, 16(1): 68-74. DOI: 10.7150/ijms.27595. ［17］ Zhu ZY, Wang XL, Li DP. Silencing of MEOX1 gene inhibits proliferation and promotes apoptosis of LNCaP cells in prostate cancer［J］. Cancer Biother Radiopharm, 2019, 34(2): 91-102. DOI: 10.1089/cbr.2018.2545. ［18］ Linn SC, West RB, Pollack JR, et al. Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans［J］. Am J Pathol, 2003, 163(6): 2383-2395. DOI: 10.1016/S00029440(10)635936. ［19］ Rodrigo I, Bovolenta P, Mankoo BS, et al. Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter［J］. Mol Cell Biol, 2004, 24(7): 2757-2766. ［20］ Lu D, Wang J, Li J, et al. Meox1 accelerates myocardial hypertrophic decompensation through Gata4［J］. Cardiovasc Res, 2018, 114(2): 300-311. DOI: 10.1093/cvr/cvx222. ［21］ Savage J, Voronova A, Mehta V, et al. Canonical Wnt signaling regulates Foxc1/2 expression in P19 cells［J］. Differentiation, 2010, 79(1): 31-40. DOI: 10.1016/j.diff.2009.08.008. ［22］ Stamataki D, Kastrinaki M, Mankoo BS, et al. Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors［J］. FEBS Lett, 2001, 499(3): 274-278. ［23］ Wissmüller S, Kosian T, Wolf M, et al. The highmobilitygroup domain of Sox proteins interacts with DNAbinding domains of many transcription factors［J］. Nucleic Acids Res, 2006, 34(6): 1735-1744. DOI: 10.1093/nar/gkl105.

[1]	刘娜, 寇介丽, 杨枫, 刘桃桃, 李丹萍, 韩君蕊, 杨立洲. 血清miR-106b-5p、miR-760联合低剂量螺旋CT诊断早期肺癌的临床价值[J]. 国际肿瘤学杂志, 2024, 51(6): 321-325.
[2]	杨蜜, 别俊, 张加勇, 邓佳秀, 唐组阁, 卢俊. 局部晚期可切除食管癌新辅助治疗疗效及预后分析[J]. 国际肿瘤学杂志, 2024, 51(6): 332-337.
[3]	袁健, 黄燕华. Hp-IgG抗体联合血清DKK1、sB7-H3对早期胃癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(6): 338-343.
[4]	陈红健, 张素青. 血清miR-24-3p、H2AFX与肝癌患者临床病理特征及术后复发的关系研究[J]. 国际肿瘤学杂志, 2024, 51(6): 344-349.
[5]	郭泽浩, 张俊旺. PFDN及其亚基在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2024, 51(6): 350-353.
[6]	张百红, 岳红云. 新作用机制的抗肿瘤药物进展[J]. 国际肿瘤学杂志, 2024, 51(6): 354-358.
[7]	许凤琳, 吴刚. EBV在鼻咽癌肿瘤免疫微环境和免疫治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 359-363.
[8]	王盈, 刘楠, 郭兵. 抗体药物偶联物在转移性乳腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 364-369.
[9]	张蕊, 褚衍六. 基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 370-375.
[10]	高凡, 王萍, 杜超, 褚衍六. 肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.
[11]	王丽, 刘志华, 杨伟洪, 蒋凤莲, 李全泳, 宋浩杰, 鞠文东. ROS1突变肺腺鳞癌合并脑梗死为主要表现的Trousseau综合征1例[J]. 国际肿瘤学杂志, 2024, 51(6): 382-384.
[12]	刘静, 刘芹, 黄梅. 基于SMOTE算法的食管癌放化疗患者肺部感染的预后模型构建[J]. 国际肿瘤学杂志, 2024, 51(5): 267-273.
[13]	杨琳, 路宁, 温华, 张明鑫, 朱琳. 炎症负荷指数与胃癌临床关系研究[J]. 国际肿瘤学杂志, 2024, 51(5): 274-279.
[14]	王俊毅, 洪楷彬, 纪荣佳, 陈大朝. 癌结节对结直肠癌根治性切除术后肝转移的影响[J]. 国际肿瘤学杂志, 2024, 51(5): 280-285.
[15]	张宁宁, 杨哲, 檀丽梅, 李振宁, 王迪, 魏永志. 宫颈细胞DNA倍体分析联合B7-H4和PKCδ对宫颈癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(5): 286-291.

同源盒基因MEOX1在肿瘤中的研究进展

Advances of homeobox gene MEOX1 in tumors

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价