国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (8): 539-543.doi: 10.3760/cma.j.issn.1673-422X.2018.09.006

• 论著 • 上一篇    下一篇

基于病例对照研究设计的代谢综合征 与结直肠癌的相关性研究

廉颖,王林平,梁婧,唐芳   

  1. 250014 济南，山东大学附属千佛山医院病案管理科（廉颖、王林平），肿瘤内科（梁婧），健康医疗大数据
    研究中心（唐芳）
  • 出版日期:2018-09-08 发布日期:2018-11-15
  • 通讯作者: 唐芳 E-mail:tangfangsdu@126.com
  • 基金资助:

     山东省自然科学基金（ZR2015HL102、ZR2015HL104）；山东省重点研发计划（2016GSF201075）

Association between metabolic syndrome and colorectal carcinoma based on a casecontrol study

Lian Ying, Wang Linping, Liang Jing, Tang Fang   

  1. Department of Medical Record Management, Qianfoshan Hospital Affiliated to Shandong University, Ji′nan 250014, China
  • Online:2018-09-08 Published:2018-11-15
  • Contact: Tang Fang E-mail:tangfangsdu@126.com
  • Supported by:

    Natural Science Foundation of Shandong Province of China (ZR2015HL102, ZR2015HL104); Shandong Provincial Key Research and Development Program (2016GSF201075)

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摘要： 目的探讨代谢综合征与结直肠癌的相关性。方法以2013至2016年间山东大学附属千佛山医院收治的900例结直肠癌患者为病例组，选取同时期该医院健康管理中心的1 774例体检者为对照组。利用logistic回归模型分析代谢综合征与结直肠癌的关系。结果病例组代谢综合征患病率为35.4%，高于对照组的27.0%，差异有统计学意义（χ2=20.33，P<0.01）。多因素logistic回归分析结果显示，代谢综合征是结直肠癌的危险因素（OR=1.38，95%CI为1.08~1.75， χ2=17.68，P＜0.01）；存在2个、3个及以上代谢综合征组分者，结直肠癌的发生风险分别是无代谢综合征组分者的1.37倍、1.60倍；此外，代谢综合征（χ2=5.40，P=0.02）及其组分（χ2=8.66，P<0.01）与结直肠癌的关系存在性别差异。结论代谢综合征及其组分是结直肠癌的危险因素，随着代谢综合征组分数的增加，发生结直肠癌的风险增加。

关键词: 代谢综合征X, 结直肠肿瘤, 病例对照研究

Abstract: ObjectiveTo evaluate the association between metabolic syndrome and colorectal carcinoma. MethodsA total of 900 patients with colorectal carcinoma  from 2013 to 2016 in Qianfoshan Hospital Affiliated to Shandong University were selected as the case group and 1 774 noncolorectal carcinoma participants from health management center as the control group. Logistic regression model was used to identify the relationship between metabolic syndrome and colorectal carcinoma. ResultsCompared with the controls (27.0%), metabolic syndrome was more prevalent among cases (35.4%). The difference was statistically significant (χ2=20.33, P<0.01). Multivariate logistic regression analyses showed that metabolic syndrome as an entity increased colorectal carcinoma risk (OR=1.38, 95%CI: 1.081.75, χ2=17.68, P＜0.01). Subjects with 2 and 3 or more components of the metabolic syndrome had an increased risk of colorectal carcinoma, and the ORs of colorectal carcinoma were 1.37 and 1.60, respectively. Genderspecific patterns were also observed in the association between metabolic syndrome, component and colorectal carcinoma (χ2=5.40, P=0.02; χ2=8.66, P<0.01). ConclusionMetabolic syndrome is associated with the occurrence of colorectal carcinoma. An increasing trend in risk of colorectal carcinoma with the number of metabolic syndrome components is observed.

Key words: Metabolic syndrome X, Colorectal neoplasms, Casecontrol studies