国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (7): 423-426.doi: 10.3760/cma.j.issn.1673-422X.2018.07.008

• 综述 • 上一篇    下一篇

β2微球蛋白与肿瘤

王娟,钟春生,张朝阳   

  1. 233000蚌埠医学院附属蚌埠市第三人民医院肿瘤内科（王娟、钟春生）；蚌埠医学院第一附属医院肿瘤外科（张朝阳）
  • 出版日期:2018-07-08 发布日期:2018-07-31
  • 通讯作者: 钟春生, Email: 1729525052@qq.com E-mail:1729525052@qq.com

Beta 2-microglobulin and tumors

Wang Juan, Zhong Chunsheng, Zhang Chaoyang   

  1. Department of Oncology, Third People′s Hospital of Bengbu, Affiliated to Bengbu Medical College, Bengbu 233000, China
  • Online:2018-07-08 Published:2018-07-31
  • Contact: Zhong Chunsheng, Email: 1729525052@qq.com E-mail:1729525052@qq.com

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摘要： β2微球蛋白（β2-MG）在正常机体的组织和细胞中表达水平低，而在肿瘤组织和细胞中表达水平升高，主要功能是参与调控肿瘤细胞中信号传导，促进肿瘤细胞生长及血管生成，并且与肿瘤的发生、发展、转移及预后相关，可作为肿瘤判断预后的重要指标。目前已在多种肿瘤细胞中证实，以β2-MG为靶点的抗肿瘤药物有望成为肿瘤新一代的靶向药物。

关键词: &beta, 2微球蛋白, 肿瘤, 预后

Abstract: Beta 2-microglobulin (β2-MG) has low expression levels in tissues and cells of normal organisms, but its expression levels is increasing in tumor. The main function of β2-MG is to regulate signal transduction in tumor cells and promote tumor cell growth and angiogenesis. High level expression of β2-MG is associated with the occurrence, progression, metastasis and prognosis of human tumors and can serve as an independent indicator of tumor prognosis. It has been confirmed in a variety of tumor cells that agent targeting β2-MG is expected to become a new generation of targeted drugs.

Key words: Beta 2-microglobulin, Neoplasms, Prognosis