国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (12): 914-917.doi: 10.3760/cma.j.issn.1673-422X.2017.12.008

• 综述 • 上一篇    下一篇

α干扰素诱导蛋白27与肿瘤

刘洪璐,刘馨,陈艳,李萍,王熙才   

  1. 650118 云南省肿瘤医院 昆明医科大学第三附属医院肿瘤研究所
  • 出版日期:2017-12-08 发布日期:2017-12-01
  • 通讯作者: 王熙才，Email: wangxc2005323@126.com E-mail: wangxc2005323@126.com
  • 基金资助:
    国家自然科学基金 (81460358)；云南省科技厅-昆明医科大学应用基础研究联合专项（2014FB066）；云南省卫生科技计划项目（2014NS023、2014NS024）；云南省詹启敏院士工作站基金（2015IC002）

Interferon alpha-inducible protein 27 and tumor

Liu Honglu, Liu Xin, Chen Yan, Li Ping, Wang Xicai   

  1. Tumor Research Institute of Third Affiliated Hospital of Kunming Medical University ＆ Yunnan Tumor Hospital, Kunming 650118, China
  • Online:2017-12-08 Published:2017-12-01
  • Contact: Wang Xicai, Email: wangxc2005323@126.com E-mail: wangxc2005323@126.com
  • Supported by:
    National Natural Science Foundation of China (81460358); Applied and Basic Research Foundation of Yunnan Provincial Science and Technology Department-Kunming Medical University (2014FB066); Project of Medical and Health Technology Development Program of Yunnan Province of China (2014NS023, 2014NS024); Zhan Qimin Academician Workstation Project of Yunnan Province of China (2015IC002)

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摘要： α干扰素诱导蛋白27（IFI27）是近年来发现的一种重要蛋白，参与细胞凋亡、细胞自噬、溶瘤作用、机体免疫调节等多种生物学功能。IFI27在乳腺癌、卵巢癌、肝癌、鳞状细胞癌等肿瘤中主要发挥促进肿瘤发展的作用。另有研究表明IFI27通过与信号传导及转录激活因子1、微小RNA、干扰素调节因子4等基因相互作用发挥促肿瘤发展的作用。IFI27有望成为监测肿瘤发生发展的标志物，为肿瘤治疗提供新靶点。

关键词: 细胞凋亡, 肿瘤, α干扰素诱导蛋白27

Abstract: Interferon alpha-inducible protein 27 (IFI27) is a newly discovered protein that participates in biological functions such as apoptosis, cell autophagy, oncolytic and immunoregulation. It also plays a major role in promoting tumor development, such as in breast cancer, ovarian cancer, liver cancer, squamous cell carcinoma and so on. Besides, studies have shown that IFI27 can interact with signal transducer and activator of transcription 1, microRNAs, interferon regulatory factor 4 and other genes, which promotes the development of tumors. Therefore, IFI27 is expected to be a marker for the occurrence and development of tumors, providing a new target for cancer therapy.

Key words: Apoptosis, Neoplasms, Interferon alpha-inducible protein 27