水通道蛋白1与恶性肿瘤的相关性

doi:10.3760/cma.j.issn.1673-422X.2017.07.009

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (7): 516-518.doi: 10.3760/cma.j.issn.1673-422X.2017.07.009

水通道蛋白1与恶性肿瘤的相关性

李萍，刘馨，刘洪璐，王熙才

650118昆明医科大学第三附属医院云南省肿瘤医院肿瘤研究所

收稿日期:2016-10-28 出版日期:2017-07-08 发布日期:2017-06-20
通讯作者: 王熙才 E-mail:wangxc2005323@126.com
基金资助:
国家自然科学基金（81460358）；云南省詹启敏院士工作站资助项目（2015IC002）；云南省科技厅昆明医科大学应用基础研究联合专项（2014FB066）；云南省应用基础研究计划（2011FZ133）

Association between aquaporin 1 and malignant tumors

Li Ping, Liu Xin, Liu Honglu, Wang Xicai

Cancer Institute of Yunnan Tumor Hospital ﹠ Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China

Received:2016-10-28 Online:2017-07-08 Published:2017-06-20
Contact: Wang Xicai E-mail:wangxc2005323@126.com

摘要/Abstract

摘要： 水通道蛋白1（AQP1）是细胞膜上特异性通道蛋白家族中的一类，主要介导水等小分子溶质的跨生物膜转运。现有研究表明，与正常组织对比，AQP1在恶性肿瘤中显著高表达，对肿瘤细胞的增殖、迁移以及血管生成等病理过程产生影响，AQP1有望成为疾病早期筛选、诊断、治疗、判断预后的分子标志。

关键词: 肿瘤, 水通道蛋白1, 分子靶向治疗

Abstract: Aquaporin1 (AQP1) is a member of a family of specific channel proteins which could mediate the transbiofilm transportation of small molecules such as water. Recent studies have shown that AQP1 is highly expressed in cancer tissues. It also has an effect on the proliferation and migration of cancer cells, angiogenesis in cancer and so on. AQP1 is expected to be a marker of screening, diagnosis, treatment and prognosis at tumor early stage.

Key words: Neoplasms, Aquaporin 1, Molecular targeted therapy

李萍，刘馨，刘洪璐，王熙才. 水通道蛋白1与恶性肿瘤的相关性[J]. 国际肿瘤学杂志, 2017, 44(7): 516-518.

Li Ping, Liu Xin, Liu Honglu, Wang Xicai. Association between aquaporin 1 and malignant tumors[J]. Journal of International Oncology, 2017, 44(7): 516-518.

参考文献

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水通道蛋白1与恶性肿瘤的相关性

Association between aquaporin 1 and malignant tumors

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