双氢青蒿素的抗肿瘤作用机制

doi:10.3760/cma.j.issn.1673-422X.2017.06.012

摘要/Abstract

摘要： 双氢青蒿素是青蒿的活性成分之一，可通过与铁离子形成自由基杀伤肿瘤细胞、诱导细胞凋亡、抗肿瘤血管生成、抑制肿瘤侵袭转移、逆转多药耐药、影响细胞内Ca2+浓度、调控细胞周期、调节细胞自噬和免疫系统等方式参与抗肿瘤过程，是潜在可利用的抗肿瘤新药。

关键词: 青蒿素类, 肿瘤, 细胞凋亡, 细胞增殖, 双氢青蒿素

Abstract: Dihydroartemisinin (DHA), the major active metabolite of artemisinin, participates in tumor progression through the following ways: forming free radicals to induce cancer cells death dependent on iron, inducing apoptosis, inhibiting angiogenesis, tumor cells invasion and metastasis, modulating multidrug resistance, controlling intracellular Ca2+ concentration, regulating cell cycles, cell autophagy and the immune system and so on. Generally, it is considered to be a potential antitumor drug.

Key words: Artemisinins, Neoplasms, Apoptosis, Cell proliferation, Dihydroartemisinin

彭文苗，付红星，余丽芳，饶智国. 双氢青蒿素的抗肿瘤作用机制[J]. 国际肿瘤学杂志, 2017, 44(6): 448-.

Peng Wenmiao, Fu Hongxing, Yu Lifang, Rao Zhiguo. Mechanism of anti-tumor effect of dihydroartemisinin[J]. Journal of International Oncology, 2017, 44(6): 448-.

参考文献

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