肿瘤放疗对免疫功能的影响

doi:10.3760/cma.j.issn.1673-422X.2015.06.013

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (6): 448-451.doi: 10.3760/cma.j.issn.1673-422X.2015.06.013

肿瘤放疗对免疫功能的影响

孔月虹,丁继平,涂文勇

200011上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科

收稿日期:2014-11-05 出版日期:2015-06-08 发布日期:2015-05-31
通讯作者: 涂文勇，Email:tu4you@163.com E-mail:tu4you@163.com
基金资助:
CSCO-默克雪兰诺肿瘤研究基金（Y-MT2014-004）

Effect of tumor radiotherapy on the immune response

Kong Yuehong, Ding Jiping, Tu Wenyong

Department of Oral & Maxillofacial Head & Neck Oncology, Shanghai Ninth People′s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China

Received:2014-11-05 Online:2015-06-08 Published:2015-05-31
Contact: Tu Wenyong E-mail:tu4you@163.com

摘要/Abstract

摘要： 肿瘤放疗能够影响机体免疫，最新研究显示适当的放疗方式能够通过调节肿瘤微环境、激活免疫细胞、释放死亡危险信号而激活免疫，产生旁观者或远位效应。随着放疗与免疫联合治疗临床评价指标研究及临床试验的开展，将有望改变传统的肿瘤治疗模式。

关键词: 放射疗法, 肿瘤, 免疫疗法, 旁观者效应

Abstract: Tumor radiation therapy (RT) can affect the immune system. Latest studies show that appropriate RT can activate the immune system through regulating tumor microenvironment, activating immune cells and releasing danger signals, and can produce bystander or abscopal effect. With the development of clinical biomarkers research and clinical trials about RT combined with immunotherapy, it is expected to change the traditional pattern of tumor treatment.

Key words: Radiotherapy, Neoplasms, Immunotherapy, Bystander effect

孔月虹,丁继平,涂文勇. 肿瘤放疗对免疫功能的影响[J]. 国际肿瘤学杂志, 2015, 42(6): 448-451.

Kong Yuehong, Ding Jiping, Tu Wenyong. Effect of tumor radiotherapy on the immune response[J]. Journal of International Oncology, 2015, 42(6): 448-451.

参考文献

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肿瘤放疗对免疫功能的影响

Effect of tumor radiotherapy on the immune response

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