Trim蛋白家族与肿瘤

doi:10.3760/cma.j.issn.1673-422X.2015.06.011

摘要/Abstract

摘要： 研究发现部分Trim蛋白家族成员与肿瘤发生发展过程相关。不同的Trim家族成员在肺癌、肝癌、结直肠癌、胃癌、乳腺癌等肿瘤中呈差异性表达，并通过调控p53活性、核转录因子-κB信号通路等影响肿瘤相关基因的表达，参与肿瘤进程。Trim家族成员可以作为抑癌基因或癌基因影响肿瘤细胞的增殖、分化、凋亡、侵袭迁移等生物学过程。

关键词: 泛素化, 肿瘤, 基因,p53, 三基序蛋白

Abstract: Studies show that some Trim family proteins are associated with tumorigenesis and cancer progression. Trim members are differently expressed in various cancers including lung cancer, hepatocellular carcinoma, colon cancer, stomach cancer and breast cancer. Trim proteins are found to be involved in tumor progess by modulating the expression of tumor associated genes via several signaling pathways such as p53 and NFκB pathway. Members of Trim family can be used as oncogenes or antioncogenes in the biological processes such as tumor cell proliferation, cell differentiation, cell apoptosis and metastasis.

Key words: Ubiquitination, Neoplasms, Genes, p53, Tripartite motif protein

杨清梅,徐祖敏,官成浓. Trim蛋白家族与肿瘤[J]. 国际肿瘤学杂志, 2015, 42(6): 442-444.

Yang Qingmei, Xu Zumin, Guan Chengnong. Trim family and tumor[J]. Journal of International Oncology, 2015, 42(6): 442-444.

参考文献

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