结直肠癌鼠及细胞株中茶多酚对结直肠癌防治作用的系统评价

doi:10.3760/cma.j.issn.1673-422X.2015.06.008

摘要/Abstract

摘要： 目的探讨结直肠癌鼠及细胞株中茶多酚对结直肠癌的防治作用。方法用计算机检索中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普中文科技期刊全文数据库（VIP）、万方医药期刊全文数据库、PubMed、Medline、EMBase和Cochrane Library等数据库收录的相关资料。查找含有使用茶多酚的结直肠癌动物模型及细胞模型的文献，检索时限为建库至2014年6月 1日，同时手动检索纳入文献的参考文献。按纳入排除标准由两人独立进行随机对照资料的筛选、提取和质量评价后，应用RevMan5.2软件进行Meta分析。结果经筛选纳入17篇文献，纳入实验大鼠305只，结直肠癌细胞5株，各分为接受茶多酚处理组及对照组。①异常隐窝病灶(ACF)：标准化均数差(SMD)=-3.64(95%CI为-5.73～-1.54， Z=3.40,P=0.000 7)，经茶多酚处理后结直肠癌实验动物的ACF数较对照组减少，茶多酚治疗有效。②平均每只鼠带瘤数：SMD=-0.83(95%CI为-1.14～-0.51， Z=5.18, P=0.000 01)，经茶多酚处理后实验组较对照组平均每只鼠带瘤数下降。③细胞周期G1期：SMD=1.85(95%CI为0.03～3.66，Z=1.99,P=0.05)，经茶多酚处理后实验组的结直肠癌细胞较多停滞于G1期。④细胞周期S期：SMD=-2.64(95%CI为-4.38～-0.90，Z=2.98,P=0.003），经茶多酚处理后实验组的S期细胞较对照组少。结论在结直肠癌鼠及细胞株中茶多酚对结直肠癌有防治作用。

关键词: 茶, 结直肠肿瘤, 细胞周期, 异常隐窝病灶

Abstract: Objective To evaluate the chemoprevention and therapy of tea polyphenol of colorectal cancer in colon cancer rats and cells. Methods Such database as CBM, CNKI, VIP, Wanfang, PubMed, Medline, EMBase, Cochrane Library were searched for collecting the papers including using tea polyphenol as a therapy and chemoprevention of colorectal cancer in colorectal cancer rats and colorectal cells, from their establishment to June 1, 2014, and the references of those related papers were also searched by hand. After studying selection, assessment and data extraction were conducted by two reviewers. RevMan5.2 software was used for Meta-analyze. Results Seventeen studies were included. Three hundred and five rats and 5 colorectal cell lines were used to the research, they were divided into the study group (received the tea treatment) and the control group (not received the tea treatment). The results of metaanalyses showed that: ① Aberrant crypt foci (ACF): standardized mean difference SMD=-3.69(95%CI为-5.85～-1.54， Z=3.40, P=0.000 8), which indicated that tea polyphenol could reduce the number of ACF. ② The average number of tumors per rat: SMD=-0.83 (95%CI: -1.14～-0.51, Z=5.18, P=0.000 01), which indicated that tea polyphenol could reduce the average number of tumors per rat. ③ Cell cycle G1 phase: SMD=1.85(95%CI: 0.03～3.66, Z=1.99,P=0.05), which indicated that tea polyphenol could increase the cell in G1 phase. ④ Cell cycle S phase: SMD=-2.64(95%CI: -4.38～-0.90, Z=2.98, P=0.003), which indicated that tea polyphenol could decrease colon cancer cell in S phase. Conclusion Tea polyphenol has a positive effect on colon cancer cell and colon cancer rats.

Key words: Tea, Colorectal neoplasms, Cell cycle, Aberrant crypt foci

刘玉婷,齐健. 结直肠癌鼠及细胞株中茶多酚对结直肠癌防治作用的系统评价[J]. 国际肿瘤学杂志, 2015, 42(6): 430-435.

Liu Yuting, Qi Jian. Chemoprevention and therapy of tea polyphenol of colorectal cancer in colorectal cancer rats and cells: a systematic review[J]. Journal of International Oncology, 2015, 42(6): 430-435.

参考文献

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