转化生长因子-β1在肿瘤干细胞中的作用

doi:10.3760/cma.j.issn.1673-422X.2014.12.005

摘要/Abstract

摘要： 肿瘤组织中存在的肿瘤干细胞是肿瘤转移和复发的根源，而转化生长因子β1（TGFβ1）在肿瘤干细胞的增殖分化过程中有着重要的调节作用，目前在许多肿瘤包括乳腺癌、肝癌、胰腺癌、肺癌、胶质瘤、胆囊癌等的肿瘤组织中发现，TGFβ1诱导的上皮间质转化（EMT）能够抑制肿瘤细胞增殖，同时富集肿瘤干细胞，增加肿瘤的侵袭和耐药能力。

关键词: 转化生长因子&beta, 1, 肿瘤干细胞

Abstract: Tumor stem cells are responsible for metastasis and relapse of cancer. Transforming growth factorβ1 (TGFβ1) plays an important role in the proliferation and differentiation of tumor stem cells. In many cancers such as breast carcinoma, hepatocellular carcinoma, pancreatic carcinoma, lung carcinoma, glioma and gallbladder carcinoma, the epithelialmesenchymal transition (EMT) induced by TGFβ1 can inhibit proliferation of cancer cell, enrich tumor stem cells and increase invasive capability and drug resistance of cancer.

Key words: Transforming growth factor beta 1, Neoplastic stem cells

马玉磊, 李海元, 周川, 周逢海, 吕海迪, 王施广. 转化生长因子-β1在肿瘤干细胞中的作用[J]. 国际肿瘤学杂志, 2014, 41(12): 893-895.

MA Yu-Lei, LI Hai-Yuan, ZHOU Chuan, ZHOU Feng-Hai, 吕Hai-Di , WANG Shi-Guang. Roles of transforming growth factor-β1 in cancer stem cells[J]. Journal of International Oncology, 2014, 41(12): 893-895.

参考文献

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