4-硝基喹啉-1-氧化物诱导小鼠食管鳞状细胞癌模型的研究进展

doi:10.3760/cma.j.cn371439-20230227-00084

国际肿瘤学杂志 ›› 2023, Vol. 50 ›› Issue (7): 437-441.doi: 10.3760/cma.j.cn371439-20230227-00084

4-硝基喹啉-1-氧化物诱导小鼠食管鳞状细胞癌模型的研究进展

李金歌¹, 李晶², 张振悍¹, 郭建鑫¹, 王景普¹, 吴忠冰³()

¹河北医科大学中西医结合学院，石家庄 050017
²河北医科大学第四医院中医科，石家庄 050019
³河北医科大学中西医结合学院中医基础教研室，石家庄 050017

收稿日期:2023-02-27 修回日期:2023-06-07 出版日期:2023-07-08 发布日期:2023-08-03
通讯作者: 吴忠冰，Email： wzb20181103@126.com
基金资助:
国家自然科学基金(82274593);河北医科大学2022年大学生创新性实验计划(USIP2022079)

Research progress of 4-nitroquinoline-1-oxide-induced esophageal squamous cell carcinoma model in mice

Li Jinge¹, Li Jing², Zhang Zhenhan¹, Guo Jianxin¹, Wang Jingpu¹, Wu Zhongbing³()

¹School of Integrated Chinese and Western Medicine，Hebei Medical University，Shijiazhuang 050017，China
²Department of Traditional Chinese Medicine，The Fourth Hospital of Hebei Medical University，Shijiazhuang 050019，China
³Basic Research Office of Traditional Chinese Medicine，School of Integrated Chinese and Western Medicine，Hebei Medical University，Shijiazhuang 050017，China

Received:2023-02-27 Revised:2023-06-07 Online:2023-07-08 Published:2023-08-03
Contact: Wu Zhongbing，Email： wzb20181103@126.com
Supported by:
National Natural Science Foundation of China(82274593);Hebei Medical University 2022 Undergraduate Innovative Experimental Program(USIP2022079)

摘要/Abstract

摘要：

食管鳞状细胞癌（ESCC）是最常见的恶性肿瘤之一，预后较差。4-硝基喹啉-1-氧化物（4NQO）是一种水溶性的喹啉衍生物，在体内可以成功诱导鳞状上皮细胞癌的产生。建立并优化4NQO诱导小鼠ESCC形成的实验方法可以为ESCC研究提供更适宜的原位模型。

关键词: 4-硝基喹啉-1-氧化物, 食道鳞癌

Abstract:

Esophageal squamous cell carcinoma （ESCC） is one of the most common malignant tumors with a poor prognosis. 4-nitroquinoline-1-oxide （4NQO） is a water-soluble quinoline derivative that can successfully induce the production of squamous cell carcinoma in vivo. Establishing and optimizing experimental methods for 4NQO induced ESCC formation in mice can provide a more suitable in situ model for the study of ESCC.

Key words: 4-nitroquinoline-1-oxide, Esophageal squamous cell carcinoma

李金歌, 李晶, 张振悍, 郭建鑫, 王景普, 吴忠冰. 4-硝基喹啉-1-氧化物诱导小鼠食管鳞状细胞癌模型的研究进展[J]. 国际肿瘤学杂志, 2023, 50(7): 437-441.

Li Jinge, Li Jing, Zhang Zhenhan, Guo Jianxin, Wang Jingpu, Wu Zhongbing. Research progress of 4-nitroquinoline-1-oxide-induced esophageal squamous cell carcinoma model in mice[J]. Journal of International Oncology, 2023, 50(7): 437-441.

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4-硝基喹啉-1-氧化物诱导小鼠食管鳞状细胞癌模型的研究进展

Research progress of 4-nitroquinoline-1-oxide-induced esophageal squamous cell carcinoma model in mice

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