国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (12): 890-893.doi: 10.3760/cma.j.issn.1673-422X.2014.12.004

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X染色体耦联锌指蛋白在肿瘤发生发展中的研究进展

  

  1. 苏州大学医学部(闫磊磊);上海交通大学附属第六人民医院普外科(彭佳远、汪昱)  
  • 出版日期:2014-12-24 发布日期:2015-02-02
  • 通讯作者: 汪昱,Email: wangyu11122@sina.com

Role of zincfinger protein X-linked in the development of neoplasms

  1. Department of Medicine, Soochow University, Suzhou 215000, China
  • Online:2014-12-24 Published:2015-02-02
  • Contact: Wang Yu, Email: wangyu11122@sina.com

摘要: X染色体耦联锌指蛋白(Zfx)是锌指蛋白家族的一员,在多种干细胞和恶性肿瘤细胞中异常表达,研究表明其在干细胞的自我更新以及肿瘤细胞增殖、凋亡和迁移等方面发挥重要的作用。

关键词: 肿瘤, 干细胞, X染色体耦联锌指蛋白

Abstract: Zincfinger protein Xlinked is a member of zinc finger protein family. Its abnormal expression has been found in a variety of stem cells and malignant tumor cells. Recent studies have shown that it plays an important role in stem cell selfrenewal and cancer cell proliferation, apoptosis and migration.

Key words: Neoplasms, Stem cells, Zincfinger protein X-linked