国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 682-685.doi: 10.3760/cma.j.issn.1673422X.2017.09.010

• 综述 • 上一篇    下一篇

非诺贝特的抗肿瘤作用

沈雅婷,胡端敏   

  1. 215004 苏州大学附属第二医院消化科
  • 出版日期:2017-09-08 发布日期:2017-10-31
  • 通讯作者: 胡端敏，Email: huduanmin@163.com E-mail:huduanmin@163.com
  • 基金资助:

    苏州市科技计划（SYS201632）

Anticancer properties of fenofibrate

Shen Yating, Hu Duanmin   

  1. Department of Gastroenterology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China
  • Online:2017-09-08 Published:2017-10-31
  • Contact: Hu Duanmin E-mail:huduanmin@163.com
  • Supported by:

    Science and Technology Planning Project of Suzhou of China (SYS201632)

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摘要： 非诺贝特作为临床常见的降脂药，主要通过激活过氧化物酶体增殖物激活受体α（PPRAα）产生降脂作用。研究表明非诺贝特可以通过抑制肿瘤细胞增殖代谢、抑制新生血管形成、阻滞细胞周期、抑制细胞运动迁移、诱导细胞凋亡等来发挥抗肿瘤作用，且以上作用不全依赖PPRAα途径。非诺贝特不良反应小，有望辅助肿瘤临床内科治疗。

关键词: 普鲁脂芬, 肿瘤, 细胞凋亡, 细胞周期

Abstract: Fenofibrate is a common lipidlowing drug activating peroxisome proliferatoractivated receptor alpha (PPRAα). Recent studies have found that fenofibrate possesses anticancer properties. Its specific mechanisms include inhibiting cell metabolism and formation of new tumor vessels, arresting cell circle, weakening cell motility, and inducing cell apoptosis. Those properties are partly independent of PPRAα. Due to its low sideeffects, it′s hopefully to be used as an anticancer adjuvant drug.

Key words: Procetofen, Neoplasms, Apoptosis, Cell cycle