国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (8): 681-683.doi: 10.3760/cma.j.issn.1673422X.2016.09.010

• 综述 • 上一篇    下一篇

微小RNA在二甲双胍抗肿瘤机制中的作用

杨利波,吕小红,武顺,岳峰,张铁   

  1. 271000 泰安市中心医院内分泌一科
  • 出版日期:2016-09-08 发布日期:2016-08-04
  • 通讯作者: 张铁，Email: tazhangtie@163.com E-mail:tazhangtie@163.com
  • 基金资助:

    山东省自然科学基金（ZR2015HL028）；泰安市科技发展计划（201449B）

Roles of microRNAs in the antitumor effects of metformin

Yang Libo, Lyu Xiaohong, Wu Shun, Yue Feng, Zhang Tie   

  1. Department of Endocrinology, Taian City Central Hospital, Taian 271000, China
  • Online:2016-09-08 Published:2016-08-04
  • Contact: Zhang Tie E-mail:tazhangtie@163.com
  • Supported by:

    Natural Science Foundation of Shandong Province of China (ZR2015HL028); Technology Development Project of Taian City of China (201449B)

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摘要： 近年来的流行病学研究提示二甲双胍具有抗肿瘤作用。然而，二甲双胍的抗肿瘤机制尚不明确。微小RNA(miRNA)可通过调节细胞的分化和增殖发挥抗肿瘤或致肿瘤生成作用。一些体外研究显示二甲双胍可调节多种与肿瘤密切相关的miRNA的表达，miRNA可能参与二甲双胍的抗肿瘤作用。

关键词: 二甲双胍, 微RNAs, 肿瘤

Abstract: Recent epidemiologic data indicate that metfomin has an antitumor effect. However, the underlying antitumor mechanisms remain unclear. MicroRNAs (miRNAs) can exhibit prooncogenic or antioncogenic effects by regulating the differentiation and proliferation of cells. In vitro studies show that metformin can regulate the expressions of multiple miRNAs which are closely associated with tumor development, a process possibly relating to the anticancer roles of metformin.

Key words: Metformin, MicroRNAs, Neoplasms