国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (8): 684-687.doi: 10.3760/cma.j.issn.1673422X.2016.09.011

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一氧化氮供体型化合物化疗增敏效应

张彩霞, 刘阳云   

  1. 410003长沙，湖南师范大学医学院第二附属医院耳鼻喉科
  • 出版日期:2016-09-08 发布日期:2016-08-04
  • 通讯作者: 刘阳云,Email： lyyundr＠aliyun.com E-mail:lyyundr＠aliyun.com
  • 基金资助:

    湖南省教育厅科研项目（14C0697）

Neoplasms chemosensitization enhancing effects of nitric oxide donor compounds

Zhang Caixia, Liu Yangyun   

  1. Department of Otolaryngology, the Second Affiliated Hospital of Hu′nan Normal University Medical College, Changsha 410003, China
  • Online:2016-09-08 Published:2016-08-04
  • Contact: Liu Yangyun E-mail:lyyundr＠aliyun.com
  • Supported by:

    The Scientific Research Project of Hunan Provincial Education Department (14C0697)

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1520

被引次数

4

摘要： 一氧化氮（NO）化疗增敏机制主要包括调节低氧诱导因子1α表达水平、经典NO信号通路、与其他分子的反应产物结合3种途径。传统NO供体型化合物硝普盐、有机硝酸酯、S亚硝基硫醇、偶氮二醇烯鎓盐、非甾体抗炎药等的抗瘤及化疗增敏效应引起了广泛的关注。

关键词: 一氧化氮供体, 肿瘤, 化学增敏剂

Abstract: The chemosensitivity enhancive mechanism on nitric oxide includes three routes: adjust the expression level of hypoxiainducible factor1α (HIF1α）, classical nitric oxide signal pathway and combine with the reaction products of other molecules. Traditional nitric oxide donor compounds include nitroferricyanide, organic nitrates, snitrosothiols, azo onium diol aldoxide, nonsteroids antiinflammatory drugs, whose function of antitumor and chemotherapy sensitization caused extensive attention.

Key words: Nitric oxide donors, Neoplasms, Chemosensitizer