国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (7): 492-494.doi: 10.3760/cma.j.issn.1673422X.2014.07.004

• 综述 • 上一篇    下一篇

核组蛋白2及其在肿瘤发生发展过程中的作用

杨逸, 茅善华, 李震洋, 顾晓冬, 项建斌, 陈宗祐   

  1. 200040 上海，复旦大学附属华山医院普外科（杨逸、李震洋、顾晓冬、项建斌、陈宗祐），泌尿外科（茅善华）
  • 出版日期:2014-08-04 发布日期:2014-08-04
  • 通讯作者: 陈宗祐，Email: 524252149@qq.com E-mail:524252149@qq.com

Nucleobindin 2 and its role in tumorigenesis and progression

YANG  Yi, MAO  Shan-Hua, LI  Zhen-Yang, GU  Xiao-Dong, XIANG  Jian-Bin, CHEN  Zong-You   

  1.  *Department of General Surgery, Huashan Hospital, Fudan University， Shanghai 200040, China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: CHEN Zong-You E-mail:524252149@qq.com

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摘要： 核组蛋白2在丘脑下部核及许多外周组织均有表达，其信号通路的研究尚不完善，神经内分泌调节、细胞存活增长、肿瘤抑制及细胞因子分泌的信号通路均有所涉及。现已经证实其与乳腺癌、肺癌、卵巢癌、前列腺癌密切相关。核组蛋白2下游可能存在多条通路与肿瘤的形成和进展相关，但仍需要进一步的实验来阐明NUCB2信号通路，为临床肿瘤防治提供可靠的依据。

关键词: 组蛋白类, 肿瘤, nesfatin1

Abstract: Nucleobindin 2 protein(NUCB2) is a newly discovered neuropeptide precursor protein, which has a comprehensive cytology function and is expressed in the hypothalamus nucleus and many peripheral tissues. There aren′t many studies about its signaling pathway, where neuroendocrine regulation, cell survival growth, tumor suppressor, cytokine secretion were found to involve in it. Besides, it has also been confirmed that breast cancer, lung cancer, ovarian cancer and prostate cancer are closely related to NUCB2. Therefore, several downstream pathways of NUCB2 may be related to the formation and progression of tumor. Further studies are still needed to clarify the signal pathways of NUCB2 to provide a reliable basis for clinical cancer prevention.

Key words: Histones, Neoplasms, Nesfatin1