国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (7): 488-492.doi: 10.3760/cma.j.issn.1673422X.2014.07.003

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表观遗传调控因子SNF5和EZH2在肿瘤发生发展中的研究进展


吴少华,单丽珠,王华庆   

  1. 300060天津医科大学肿瘤医院淋巴瘤科 国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室（吴少华、王华庆）；天津南开医院肿瘤科（单丽珠）
  • 出版日期:2014-08-04 发布日期:2014-08-04
  • 通讯作者: 王华庆，Email：huaqingw@163.com E-mail:huaqingw@163.com

Advances in the research on epigenetic regulation factors—SNF5 and EZH2 in the carcinogenesis and progress of different tumors

 WU  Shao-Hua, DAN  Li-Zhu, WANG  Hua-Qing   

  1. *Department of Lymphoma, Tianjin Medical University Cancer and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: Wang Huaqing E-mail:huaqingw@163.com

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摘要： 表观遗传调控在基因表达、DNA复制、修复和重组等重要过程中起着关键作用，表观遗传调控异常会引发多种疾病尤其是癌症。SNF5是SWISNF染色体重塑复合物的核心成分之一，具有强效抑癌作用。果蝇zeste基因增强子同源物2(EZH2)是目前与肿瘤关联密切且复杂的组蛋白甲基化酶，具有促癌功能。已有研究报道了表观遗传调控因子SNF5和EZH2在不同肿瘤发生发展中的作用及二者之间的相互关系。

关键词: 后成说, 遗传, 肿瘤, 基因沉默, EZH2

Abstract: Epigenetics refers to heritable alterations in gene expression that do not involve the DNA coding sequence itself. Epigenetic regulation plays an important role in gene expression, DNA replication, reparation and reconstitution. Thus, the abnormity of epigenetic regulation may lead to different diseases, especially cancer. SNF5, which can suppress tumor significantly, is one of the core components of SWI/SNF chromosome remodeling complexes. EZH2, a histone methyltransferase, is closely and complicatedly related to cancer and has significant effect on tumorigenesis. There are many studies reporting the effects of epigenetic regulation factors—SNF5 and EZH2 on different tumors as well as the interrelation at present. In the present paper, the advances in the research on these two epigenetic regulation factors in the carcinogenesis are reviewed.

Key words: Epigenesis, genetic, Neoplasms, Gene silencing, EZH2