外泌体在前列腺癌骨转移中的作用

doi:10.3760/cma.j.cn371439-20240522-00135

摘要/Abstract

摘要：

骨是前列腺癌最主要的转移部位，前列腺癌骨转移严重影响患者生存预后与生命质量。外泌体是由细胞分泌的具有脂质双分子层结构的囊泡，在细胞间的通讯中发挥重要作用。外泌体可调控前列腺癌细胞在骨组织中的特异性定植，塑造有利于肿瘤细胞生存的转移前生态位，并调节骨的免疫微环境。同时，外泌体也可调节成骨细胞和破骨细胞的分化与成熟过程，从而导致骨重塑。进一步了解外泌体在前列腺癌骨转移中的作用，有助于开发延缓骨转移进展的新靶点。

关键词: 前列腺肿瘤, 外泌体, 骨转移

Abstract:

Bone is the main metastatic site of prostate cancer， and bone metastasis of prostate cancer seriously affects the prognosis and quality of life of patients. Exosomes are lipid bilayer vesicles secreted by cells， which play a significant role in intercellular communication. Exosomes can regulate the specific colonization of prostate cancer cells in bone tissue， reshape the pre-metastatic niche conducive to the survival of tumor cells， and modulate the immune microenvironment of bone. At the same time， exosomes can also regulate the differentiation and maturation of osteoblasts and osteoclasts， resulting in bone remodeling. Further understanding of the role of exosomes in bone metastasis of prostate cancer will help to develop new targets for delaying the progression of bone metastasis.

Key words: Prostate neoplasms, Exosomes, Bone metastasis

黄华玉, 宋启斌. 外泌体在前列腺癌骨转移中的作用[J]. 国际肿瘤学杂志, 2024, 51(12): 794-797.

Huang Huayu, Song Qibin. Role of exosomes in bone metastasis of prostate cancer[J]. Journal of International Oncology, 2024, 51(12): 794-797.

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