中药多酚类成分抗结直肠癌作用研究进展

doi:10.3760/cma.j.cn371439-20240407-00088

摘要/Abstract

摘要：

结直肠癌（CRC）是最常见的消化系统肿瘤之一，也是死亡率居世界第二的肿瘤。当前应用于临床治疗的化疗药物因不良反应较多、易产生化疗耐药性，严重影响患者的生命质量。因此，寻找抗CRC新型药物是必要的。作为天然化合物，中药多酚类成分可以通过促进细胞凋亡、抑制细胞增殖、诱导铁死亡等多种机制发挥抗CRC特性。另外，它还可以逆转CRC细胞对化疗药物的耐药性。进一步探索中药多酚类成分抗CRC的作用机制，可为临床应用提供一定的参考依据。

关键词: 结直肠肿瘤, 多酚类, 槲皮素, 表没食子儿茶素没食子酸酯, 白藜芦醇, 姜黄素

Abstract:

Colorectal cancer （CRC） is one of the most common digestive system tumors and the second most common tumor in the world in terms of mortality. The current chemotherapeutic drugs applied in clinical treatment seriously affect the survival quality of patients due to adverse reaction and susceptibility to chemoresistance. Therefore，it is necessary to search for novel anti-CRC drugs. As natural compounds，polyphenols components of traditional Chinese medicine can exert anti-CRC properties through various mechanisms，such as promoting apoptosis，inhibiting cell proliferation，and inducing iron death. In addition，it can reverse the resistance of CRC cells to chemotherapeutic drugs. Further exploration of the anti-CRC action mechanism of polyphenols constituents of traditional Chinese medicine may provide a certain reference basis for clinical application.

Key words: Colorectal neoplasms, Polyphenols, Quercetin, Epigallocatechin gallate, Resveratrol, Curcumin

李志伟, 翟春宝. 中药多酚类成分抗结直肠癌作用研究进展[J]. 国际肿瘤学杂志, 2024, 51(8): 526-531.

Li Zhiwei, Zhai Chunbao. Research progress on the anti-cancer effect of traditional Chinese medicine polyphenols on colorectal cancer[J]. Journal of International Oncology, 2024, 51(8): 526-531.

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