单细胞视角下的肿瘤浸润免疫细胞

doi:10.3760/cma.j.cn371439-20231130-00075

摘要/Abstract

摘要：

免疫微环境与肿瘤的治疗和预后密切相关。肿瘤浸润免疫细胞在肿瘤不同阶段中异质性显著。单细胞RNA测序（scRNA-seq）在单细胞水平解析细胞的生物学行为、机制及其与机体的关系，已广泛应用于各种肿瘤微环境的研究。研究显示，应用scRNA-seq技术能深入剖析肿瘤浸润免疫细胞的免疫特征。

关键词: 单细胞分析, 淋巴细胞, 髓系细胞, 肿瘤

Abstract:

Immune microenvironment is closely related to the treatment and prognosis of tumors. Tumor-infiltrating immune cells exhibit significant heterogeneity in different stages of tumors. Single-cell RNA sequencing （scRNA-seq） is widely used in the study of various tumor microenvironment to analyze the biological behavior， mechanisms， and relationship between cells and the body at the single-cell level. The results showed that using scRNA-seq can deeply understand the immune characteristics of tumor-infiltrating immune cells.

Key words: Single-cell analysis, Lymphocytes, Myeloid cells, Neoplasms

杜启联, 胡钦勇. 单细胞视角下的肿瘤浸润免疫细胞[J]. 国际肿瘤学杂志, 2024, 51(7): 458-463.

Du Qilian, Hu Qinyong. Tumor-infiltrating immune cells from a single-cell perspective[J]. Journal of International Oncology, 2024, 51(7): 458-463.

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