复发/难治外周T细胞淋巴瘤的新药治疗进展

doi:10.3760/cma.j.cn371439-20200507-00029

摘要/Abstract

摘要：

外周T细胞淋巴瘤(PTCL)是一组起源于胸腺后成熟T细胞的异质性疾病,传统治疗往往预后不佳,尤其是复发/难治外周T细胞淋巴瘤(r/rPTCL)。近年来多种新型抗肿瘤药物在r/rPTCL的治疗中崭露头角,包括不同类型的酶抑制剂、单克隆抗体、免疫调节剂以及免疫检查点抑制剂等被证实有效,新药的发现及临床应用有望改善这类疾病的不良预后。

关键词: 淋巴瘤,T细胞,外周, 复发, 治疗, 新药

Abstract:

Peripheral T-cell lymphomas (PTCLs) are a group of heterogeneous diseases originating from post-thymic T-cells, with poor prognosis using traditional therapy, especially in patients with relapsed/refractory PTCLs (r/rPTCLs). In recent years, a variety of new anti-tumor drugs have emerged in the treatment of r/rPTCLs, including different types of enzyme inhibitors, monoclonal antibodies, immunomodulators and immune checkpoint inhibitors, which have been proved to be effective. The discovery and clinical application of new drugs are expected to improve the outcomes of the diseases.

Key words: Lymphoma,T-cell,peripheral, Recurrence, Therapy, New drugs

赵可, 王华庆. 复发/难治外周T细胞淋巴瘤的新药治疗进展[J]. 国际肿瘤学杂志, 2020, 47(6): 321-326.

Zhao Ke, Wang Huaqing. Progress of new drugs on relapsed/refractory peripheral T-cell lymphoma[J]. Journal of International Oncology, 2020, 47(6): 321-326.

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