Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (8): 625-627.doi: 10.3760/cma.j.issn.1673422X.2015.08.018

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Male breast cancer susceptibility genes

HE  Xiao-Qin, GAN  Yuan-Yuan, XU  Xi-Ming   

  1. Cancer Center, People′s Hospital of Wuhan University,Wuhan 430060, China
  • Online:2015-08-08 Published:2015-06-29
  • Contact: Xu Ximing E-mail:doctorxu120@aliyun.com

Abstract: Male breast cancer (MBC) is one of rare malignant carcinomas, of which the pathogenesis and biological characteristics remain elusive. Recently, it has been reported that breast cancer susceptibility gene (BRCA) 1, BRCA2, checkpoint kinase 2 (CHEK2) and partner and localizer of BRCA2 (PALB2) play important roles in the pathogenesis of MBC. Whereas the relationship between BRCA1interacting protein 1 (BRIP1) and MBC is still controversial.

Key words: Breast neoplasms, male, Genes