Expression and clinical significance of SIRT-1 and NF-κB in non-small cell lung cancer

doi:10.3760/cma.j.issn.1673-422X.2015.07.007

Abstract

Abstract: ObjectiveTo investigate the expression and clinical significance of silent mating type information regulation 2 homolog1 (SIRT1) and nuclear factorκB (NFκB) in nonsmall cell lung cancer (NSCLC). MethodsThe expressions of SIRT1 and NFκB were evaluated by immunohistochemistry in 108 selected cases of primary NSCLC and 48 samples of paracarcinoma normal tissue. The relationships of the expressions of SIRT1 and NFκB and clinical pathological features were analyzed, respectively. ResultsImmunohistochemical results showed that the positive expression rates of SIRT1 and NFκB in NSCLC tissue were 90.7% (98/108) and 94.4% (102/108), respectively, significantly higher than those in normal lung tissue 4.2% (2/48), 16.7% (8/48), χ2=108.237, P=0.000; χ2=96.683, P=0.000, and the expression of SIRT1 and NFκB showed a positive correlation (r=0.480, P=0.001). There were significant positive correlations between the expression of SIRT1 and tumor size （r=0.227, P=0.018）, TNM stage （r=0.298, P=0.002） and lymph node metastasis （r=0.280, P=0.003）, and there was negative correlation between the expression of SIRT1 and differentiation （r=-0.300, P=0.002）, and there were no correlation between the expression of SIRT1 and sex, age and histological type in NSCLC tissues. There were significant positive correlation between the expression of NFκB and TNM stage （r=0.256, P=0.009） and lymph node metastasis （r=0.261, P=0.006）, and there was negative correlation between the expression of NFκB and differentiation （r=-0.235, P=0.013）, and there were no correlation between the expression of NFκB and sex, age, histological type and tumor size in NSCLC tissues. ConclusionThe positive expression rates of SIRT1 and NFκB in NSCLC tissue are significantly higher than those in normal lung tissue, and they are related to TNM stage, lymph node metastasis and differentiation, and the former is also related to tumor size. High expression of SIRT1 and NFκB may play important roles in the occurrence and development of NSCLC．

Key words: irtuins, NF-kappa B, Carcinoma, non-small-cell lung, Immunohistochemistry

Jiang Zhongxiu, Liu Yang, Li Ning, Qi Xiaoying, Zhang Xiaoye. Expression and clinical significance of SIRT-1 and NF-κB in non-small cell lung cancer[J]. Journal of International Oncology, 2015, 42(7): 504-507.

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