Abstract: mTOR signaling pathway is closely related to cell proliferation, cell cycle and other pathological processes about tumor. Rapamycin plays an antitumor     effect through inhibiting mTOR, but it prone to drug resistance, which leads to limited clinical application. Its resistant mechanism is related with the activation of PI3KAkt, which is regulated with negative feedback. Dual inhibitors of related proteins of mTOR pathway  are expected to reverse the drug resistance.

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margin-bottom: 0pt, text-indent: 23.52pt, text-align: justify">font-family: '宋体', mso-spacerun: 'yes'">Sirolimus, Drug resistance, mammalian target of rapamycin