Research progress of D4-GDI in the pathogenesis of lung cancer

doi:10.3760/cma.j.issn.1673-422X.2014.03.014

Abstract

Abstract: As one of the main members of the Rho GDI dissociation inhibitory factors, D4-GDI inhibits the dissociation of Rho protein and GDP, which is also involved in a wide range of celluar functions, such as cell contraction, adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence has been suggested that D4-GDI is involved in the pathogenesis of several pulmonary diseases, such as lung cancer. Intervention of D4-GDI expression may improve the pathological changes and prognosis of these diseases.

Key words: Apoptosis, Inflammation, Signaling pathway, Lung neoplasms, D4-GDI

LUO Xin-Yue, HU Rui-Cheng, DAI Ai-Guo. Research progress of D4-GDI in the pathogenesis of lung cancer[J]. Journal of International Oncology, 2014, 41(3): 206-208.

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