Abstract: Short course chemotherapy combined with local field radiotherapy (IFRT) is an important treatment for limitedstage (Ⅰ-Ⅱ) diffuse large B cell lymphoma patients, but the value of radiotherapy has been disputed. Some patients may be cured by combined chemotherapy which contains anthracycline, but there are some patients still facing death. Therefore, researchers try to improve survival of patients further by increasing the density or intensity of the chemotherapy dose, but attempt to reduce the dose or the use of low toxicity drugs for elderly patients. In addition, researches such as radioimmunotherapy and biological targeted therapy have made certain progress.

Key words: Lymphoma, large B-cell, diffuse, Radiotherapy, Drug therapy