Dickkopf-1 and bone metastases

Abstract

Abstract: Recent studies show that the abnormalities of dickkopf-1 (DKK-1) are closely related to the bone metastasis and therapeutic effect of breast cancer, prostatic carcinoma, multiple myeloma, neuroblastoma and non-small cell lung cancer. Clinical researches of large sample on the relationships between serum DKK-1 concentration and malignant tumors bone metastases have important clinical significance for evaluating the value of DKK-1 as a clinical biological biomarker of bone metastases and understanding the tumor mechanisms of bone metastases .

Key words: Gene expression regulation, Neoplasm metastasis, Neoplasms, bone tissue

QIAO Hua, YOU Li-Na, FAN Gu-Hong. Dickkopf-1 and bone metastases[J]. Journal of International Oncology, 2012, 39(8): 626-628.

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Dickkopf-1 and bone metastases

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