Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (5): 384-386.

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Hepatocyte growth factor and its receptor in multiple myeloma

HU Cheng-lin, FU Lei-hua, CHEN Lin   

  1. Department of Hematology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
  • Online:2012-05-08 Published:2012-05-02
  • Contact: CHEN Lin, E-mail: chenlincq@sina.com E-mail:chenlincq@sina.com

Abstract: Hepatocyte growth factor (HGF), a multifunctional cytokine, plays a biological role through acting on the cell surface transmembrane receptor c-Met. The growth, invasion and metastasis of many tumors are associated with the abnormalities of HGFc-Met signaling pathway. Studies found that HGF and its receptor c-Met have close relations with the occurrence, metastasis, invasion and prognosis of multiple myeloma.

Key words: Hepatocyte growth factor, Multiple myeloma