Relationship between intestinal microecology and the occurrence and progression of colorectal cancer

doi:10.3760/cma.j.cn371439-20251119-00060

Abstract

Abstract:

The intestinal microecology consists of intestinal microorganisms and their metabolites，and is closely related to the occurrence and development of colorectal cancer. Among intestinal microorganisms，bacteria such as fusobacterium nucleatum，entero toxigenic bacteroides fragilis，and pks⁺ escherichia coli； and fungi such as candida tropicalis and candida albicans； as well as related viruses，can promote the occurrence and development of colorectal cancer through different mechanisms. Microbial metabolites exert a bidirectional effect in the occurrence and development of colorectal cancer：butyric acid，indole-3-lactic acid，ursodeoxycholic acid，etc.，play tumor-suppressive roles，while formic acid，indole-3-acrylic acid，deoxycholic acid，etc.，exert tumor-promoting effects. In-depth analysis of the functions and mechanisms of the intestinal microecology can provide theoretical references for related basic research and clinical diagnosis and treatment of colorectal cancer.

Key words: Colorectal neoplasms, Gastrointestinal microbiome, Immunomodulation

Wang Yong, Zhao Haiyan, Zhang Mingming, Wu Xinlin. Relationship between intestinal microecology and the occurrence and progression of colorectal cancer[J]. Journal of International Oncology, 2026, 53(6): 370-375.

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