Innovative applications and challenges of organoid technology in the precision treatment of lung cancer

doi:10.3760/cma.j.cn371439-20250408-00059

Abstract

Abstract:

Lung cancer organoids accurately reproduce the genetic heterogeneity and pathological features of the original tumor by 3D simulation of the tumor microenvironment and combining with CRISPR/Cas9 gene editing and multi-cell co-culture technology，thus demonstrating broad application prospects. In clinical transformation，they have been used for drug sensitivity testing（such as reversing platinum resistance）and efficacy prediction，promoting the precision of individualized diagnosis and treatment. At the same time，they have accelerated the research and development of targeted drugs（such as WEE1 inhibitors in combination with immunotherapy）and the analysis of drug resistance mechanisms. Despite challenges such as limited sample acquisition and insufficient model standardization，the potential of lung cancer organoids in revealing prognostic markers（such as IRAK1BP1）and optimizing immunotherapy strategies still provides a breakthrough research path for the precise diagnosis and treatment of lung cancer.

Key words: Lung neoplasms, Organoids, Diagnosis, Therapy

Zhou Daiyan, Zeng Xinxin, Hao Mengdi, Liu Weilu, Xie Pei, Zhang Xuhui. Innovative applications and challenges of organoid technology in the precision treatment of lung cancer[J]. Journal of International Oncology, 2026, 53(6): 366-369.

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