Research updates of RET proto-oncogene in non-small cell lung cancer

doi:10.3760/cma.j.cn371439-20241115-00039

Abstract

Abstract:

The RET protein encoded by RET proto-oncogene is a receptor tyrosine kinase that serves as a potential therapeutic target in non-small cell lung cancer （NSCLC）. In NSCLC，the incidence of RET fusions variants ranges from 1%-2% and is more common in younger，non-smoking patients. Traditional chemotherapy，immunotherapy，and multitarget kinase inhibitors have shown limited efficacy in treating RET fusion-positive NSCLC patients. However，selective RET inhibitors，such as selpercatinib and pralsetinib，have significantly improved the prognosis of those patients. The treatment strategy following resistance to selective RET inhibitors is a future research direction.

Key words: Proto-oncogene proteins c-ret, Carcinoma, non-small-cell lung, Molecular targeted therapy

Tang Lei, Cai Zongyou, Chang Jianhua. Research updates of RET proto-oncogene in non-small cell lung cancer[J]. Journal of International Oncology, 2025, 52(4): 237-241.

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