Progress of PARP inhibitors in targeted therapy of small cell lung cancer

doi:10.3760/cma.j.cn371439-20221123-00073

Abstract

Abstract:

Small cell lung cancer （SCLC） is a rapidly developing malignant tumor，which is highly heterogeneous and prone to drug resistance，and the prognosis is usually poor. Poly ADP-ribose polymerase （PARP） inhibitors target the DNA damage response pathway，preventing DNA repair，thereby exerting anti-tumor effects. Currently，PARP inhibitors are used as monotherapy or in combination with DNA-damaging agents or immune checkpoint inhibitors in the treatment of SCLC. Although the current research results are limited，it can be seen that PARP inhibitors may be a breakthrough in the targeted therapy of SCLC.

Key words: Small cell lung carcinoma, Poly（ADP-ribose） polymerase inhibitors, DNA repair, Molecular targeted therapy, Targeting preparation

Liu Li, Zhu Siqi, Sun Mengying, He Jingdong. Progress of PARP inhibitors in targeted therapy of small cell lung cancer[J]. Journal of International Oncology, 2023, 50(6): 368-372.

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