Preventive and therapeutic effects of common plant drugs on colon cancer and its mechanism

doi:10.3760/cma.j.issn.1673-422X.2020.01.010

Abstract

Abstract:

It is shown that phytochemicals have a protective effect on colon cancer. Curcumin, polysaccharides (apple polysaccharides, mushroom glucans), saponins (paridis saponins, ginsenosides), resveratrol, quercetin and other plant drugs can inhibit colon cancer cell proliferation and promote cell apoptosis through different signaling pathways. In addition, it also has anti-inflammatory, antioxidant, anti-angiogenesis, reduce the toxic side effects of chemotherapy drugs, and reverse the drug resistance of tumor cells. Understan-ding the prevention and cure effect of plant medicine on colon cancer and its possible mechanism can provide more theoretical basis and therapeutic ideas for the clinical prevention and cure of colon cancer.

Key words: Herbal drugs, Colonic neoplasms, Pharmacological action, Molecular mechanisms

Zhou Huiping, Li Yuhua, Wang Yuhui, Su Yilong, Yang Yingying, Xu Xiaotian, Duan Xiaoqun. Preventive and therapeutic effects of common plant drugs on colon cancer and its mechanism[J]. Journal of International Oncology, 2020, 47(1): 51-55.

References 34

[1]	Bray F, Ferlay J, Soerjomataram I , et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018,68(6):394-424. DOI: 10.3322/caac.21492.
[2]	Chen W, Zheng R, Baade PD , et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016,66(2):115-132. DOI: 10.3322/caac.21338.
[3]	Maresso KC, Tsai KY, Brown PH , et al. Molecular cancer prevention: current status and future directions[J]. CA Cancer J Clin, 2015,65(5):345-383. DOI: 10.3322/caac.21287.
[4]	Kumar G, Mittal S, Sak K , et al. Molecular mechanisms underlying chemopreventive potential of curcumin: current challenges and future perspectives[J]. Life Sci, 2016,148:313-328. DOI: 10.1016/j.lfs.2016.02.022.
[5]	杨芳, 刘少琼, 李春花 , 等. 姜黄素下调结直肠癌细胞Notch1信号通路研究[J]. 湖南中医药大学学报, 2015, 35(4): 10-13, 50, 封3. DOI: 10.3969/j.issn.1674-070X.2015.04.003.
[6]	Sankpal UT, Nagaraju GP, Gottipolu SR , et al. Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species[J]. Oncotarget, 2016,7(3):3186-3200. DOI: 10.18632/oncotarget.6553.
[7]	Radhakrishnan VM, Kojs P, Young G , et al. pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1)[J]. PLoS One, 2014,9(1):e85796. DOI: 10.1371/journal.pone.0085796.
[8]	Zhang L, Cheng X, Gao Y , et al. Curcumin inhibits metastasis in human papillary thyroid carcinoma BCPAP cells via down-regulation of the TGF-β/Smad2/3 signaling pathway[J]. Exp Cell Res, 2016,341(2):157-165. DOI: 10.1016/j.yexcr.2016.01.006.
[9]	陈贵娥, 唐源, 刘满英 , 等. 苹果多糖抑制人结肠癌细胞SW-620转移的作用及机制研究[J]. 现代肿瘤医学, 2019,27(12):2040-2044.
[10]	张典, 王粉侠, 弥曼 , 等. 苹果多糖预防小鼠结肠炎癌变的作用及其机制研究[J]. 中国药学杂志, 2015,50(17):1527-1531. DOI: 10.11669/cpj.2015.17.015.
[11]	Liu Y, Zhao J, Zhao Y , et al. Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer[J]. J Cell Mol Med, 2019,23(2):750-760. DOI: 10.1111/jcmm.13897.
[12]	Suga Y, Takehana K . Lentinan diminishes apoptotic bodies in the ileal crypts associated with S-1 administration[J]. Int Immunopharmacol, 2017,50:55-60. DOI: 10.1016/j.intimp.2017.06.012.
[13]	Wang J, Li W, Huang X , et al. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice[J]. Oncotarget, 2017,8(1):610-623. DOI: 10.18632/oncotarget.13481.
[14]	Li Y, Sun Y, Fan L , et al. Paris saponin Ⅶ inhibits growth of colorectal cancer cells through Ras signaling pathway[J]. Biochem Pharmacol, 2014,88(2):150-157. DOI: 10.1016/j.bcp.2014.01.018.
[15]	Zhou H, Sun Y, Zheng H , et al. Paris saponin Ⅶ extracted from trillium tschonoskii suppresses proliferation and induces apoptosis of human colorectal cancer cells[J]. J Ethnopharmacol, 2019,239:111903. DOI: 10.1016/j.jep.2019.111903.
[16]	Chen M, Ye K, Zhang B , et al. Paris saponin Ⅱ inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway[J]. Pharmacol Res, 2019,139:273-285. DOI: 10.1016/j.phrs.2018.11.029.
[17]	于思 . 重楼皂苷Ⅰ诱导ROS蓄积介导结肠癌细胞周期阻滞和自噬的研究[D]. 成都: 成都中医药大学, 2018.
[18]	Han S, Jeong AJ, Yang H , et al. Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells[J]. J Ethnopharmacol, 2016,194:83-90. DOI: 10.1016/j.jep.2016.08.039.
[19]	Wang J, Chen Y, Dai C , et al. Ginsenoside Rh2 alleviates tumor-associated depression in a mouse model of colorectal carcinoma[J]. Am J Transl Res, 2016,8(5):2189-2195.
[20]	Tang YC, Zhang Y, Zhou J , et al. Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progre-ssion in vivo[J]. Int J Oncol, 2018,52(1):127-138. DOI: 10.3892/ijo.2017.4183.
[21]	Yang X, Zou J, Cai H , et al. Ginsenoside Rg3 inhibits colorectal tumor growth via down-regulation of C/EBPβ/NF-κB signaling[J]. Biomed Pharmacother, 2017, 1240-1245. DOI: 10.1016/j.biopha.2017.11.092.
[22]	Qiu R, Qian F, Wang X , et al. Targeted delivery of 20(S)-ginse-noside Rg3-based polypeptide nanoparticles to treat colon cancer[J]. Biomed Microdevices, 2019,21(1):18. DOI: 10.1007/s10544-019-0374-0.
[23]	Phi LTH, Wijaya YT, Sari IN , et al. The anti-metastatic effect of ginsenoside Rb2 in colorectal cancer in an EGFR/SOX2-dependent manner[J]. Cancer Med, 2018,7(11):5621-5631. DOI: 10.1002/cam4.1800.
[24]	Chen H, Jin ZL, Xu H . MEK/ERK signaling pathway in apoptosis of SW620 cell line and inhibition effect of resveratrol[J]. Asian Pac J Trop Med, 2016,9(1):49-53. DOI: 10.1016/j.apjtm.2015.12.010.
[25]	Du Z, Zhou F, Jia Z , et al. The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells[J]. Iran J Basic Med Sci, 2016,19(11):1171-1176.
[26]	Demoulin B, Hermant M, Castrogiovanni C , et al. Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase Ⅱ and activates the ATM kinase to trigger p53-dependent apoptosis[J]. Toxicol In Vitro, 2015,29(5):1156-1165. DOI: 10.1016/j.tiv.2015.04.015.
[27]	Nana AW, Wu SY, Yang YS , et al. Nano-diamino-tetrac (NDAT) enhances resveratrol-induced antiproliferation by action on the RRM2 pathway in colorectal cancers[J]. Horm Cancer, 2018,9(5):349-360. DOI: 10.1007/s12672-018-0334-9.
[28]	Karimi Dermani F, Saidijam M, Amini R , et al. Resveratrol inhibits proliferation, invasion, and epithelial-mesenchymal transition by increasing miR-200c expression in HCT-116 colorectal cancer cells[J]. J Cell Biochem, 2017,118(6):1547-1555. DOI: 10.1002/jcb.25816.
[29]	Darband SG, Kaviani M, Yousefi B , et al. Quercetin: a functional dietary flavonoid with potential chemo-preventive properties in colo-rectal cancer[J]. J Cell Physiol, 2018,233(9):6544-6560. DOI: 10.1002/jcp.26595.
[30]	Roy S, Das R, Ghosh B , et al. Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer[J]. Mol Carcinog, 2018,57(6):700-721. DOI: 10.1002/mc.22792.
[31]	Ahmed HH, Aglan HA, Zaazaa AM , et al. Quercetin confers tumoricidal activity through multipathway mechanisms in a N-methylnitrosourea rat model of colon cancer[J]. Asian Pac J Cancer Prev, 2016,17(11):4991-4998. DOI: 10.22034/APJCP.2016.17.11.4991.
[32]	Yang Y, Wang T, Chen D , et al. Quercetin preferentially induces apoptosis in KRAS-mutant colorectal cancer cells via JNK signaling pathways[J]. Cell Biol Int, 2019,43(2):117-124. DOI: 10.1002/cbin.11055.
[33]	Zhang Z, Li B, Xu P , et al. Integrated whole transcriptome profiling and bioinformatics analysis for revealing regulatory pathways associ-ated with quercetin-induced apoptosis in HCT-116 cells[J]. Front Pharmacol, 2019,10:798. DOI: 10.3389/fphar.2019.00798.
[34]	Langner E, Lemieszek MK, Rzeski W . Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiprolife-rative potential in colon cancer cells in vitro[J]. J Food Biochem, 2019,43(4):e12802. DOI: 10.1111/jfbc.12802.