Abstract: Glioma is a central nervous system tumor, which originates neuroderm and expresses the high malignant degree. Due to the particularity of the usual location, it makes the treatment of glioma difficult to achieve the desired effect. Interferon is a kind of important cytokines, and it has some biological characteristics, such as inducing apoptosis, inhibiting of tumor growth, and pathological angiogenesis, regulating immune function and so on. Studies have shown that there are many key molecules in the interferon signaling pathways, and these molecules play an important role in the occurrence and development of glioma cell apoptosis. Explore the key molecules and its mechanism of action in the process of Interferon inducing glioma, which may provide new clinical strategies for diagnosis and treatment of glioma.

Key words: Interferons, Glioma, Apoptosis