Research progress of ferroptosis in cervical cancer

doi:10.3760/cma.j.cn371439-20250712-00031

Abstract

Abstract:

Cervical cancer remains a common malignancy of the female reproductive system. Postoperative metastasis，recurrence，and resistance to radiotherapy and chemotherapy pose formidable challenges. Ferroptosis，an iron-dependent form of programmed cell death，has demonstrated potential in selectively inducing cervical cancer cell death by targeting relevant molecules and signaling pathways. The development of small molecule drugs and natural active components targeting ferroptosis to reverse radiotherapy and chemotherapy resistance，as well as the construction of ferroptosis biomarker prognostic models and the exploration of combined strategies with immunotherapy，provide more possibilities for precise treatment of breast cancer. A detailed elucidation of the mechanism of ferroptosis in cervical cancer and the significance of targeting ferroptosis for cervical cancer treatment can provide certain theoretical support for the diagnosis and treatment of cervical cancer.

Key words: Uterine cervical neoplasms, Ferroptosis, Therapy

Yang Qing, He Xiyan, Sun Xiaotong. Research progress of ferroptosis in cervical cancer[J]. Journal of International Oncology, 2026, 53(3): 187-192.

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