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08 March 2026, Volume 53 Issue 3 Previous Issue   

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Original Article

Effects of lncRNA CASC19 on proliferation，migration and invasion of breast cancer cells by regulating miR-410-3p/LAMC1 signaling pathway Li Yao, Tian Lin, Liu Haolin, Xiao Jing 2026, 53 (3):  129-136.  doi: 10.3760/cma.j.cn371439-20250530-00021 Abstract ( 10 )   HTML ( 4 )   PDF (2163KB) ( 5 )   Save Objective To investigate the effects of long non-coding RNA （lncRNA） cancer susceptibility candidate 19 （CASC19） on the proliferation，migration and invasion of breast cancer cells by regulating the microRNA-410-3p （miR-410-3p）/laminin γ1 （LAMC1） signaling pathway. Methods A total of 53 pairs of breast cancer tissues and adjacent tissues of patients treated at Shiyan Renmin Hospital of Hubei Province from January 2023 to January 2024 were collected. The breast cancer MCF-7 cells were divided into the NC group，the sh-NC group，the sh-CASC19 group，the sh-CASC19+anti-NC group，and the sh-CASC19+anti-miR-410-3p group. The interaction between CASC19 and miR-410-3p，and between miR-410-3p and LAMC1 were verified by dual-luciferase reporter gene assay. The expression levels of CASC19，miR-410-3p and LAMC1 mRNA of MCF-7 cells in breast cancer tissues and adjacent tissues and in each group were detected by quantitative real-time PCR，cell proliferation was measured by EdU staining and CCK-8 assay，cell migration ability was evaluated by scratch assay，cell invasion ability was determined by Transwell assay，Western blotting was applied to detect the expression of proliferating cell nuclear antigen （PCNA），LAMC1，and matrix metalloproteinase-2 （MMP-2） proteins. Results The relative expression levels of CASC19 in adjacent tissues and breast cancer tissues were 1.01±0.30 and 1.65±0.31，respectively，miR-410-3p were 0.99±0.17 and 0.53±0.15，respectively，and LAMC1 were 1.00±0.29 and 1.48±0.31，respectively，with statistically significant differences （t=37.92，P<0.001； t=37.87，P<0.001； t=21.24，P<0.001）. The results of the dual-luciferase reporter gene assay showed that，CASC19 could target and negatively regulate miR-410-3p，and miR-410-3p could target and negatively regulate LAMC1. The relative expression levels of CASC19 in breast cancer MCF-7 cells from the NC，sh-NC，sh-CASC19，sh-CASC19+anti-NC，and sh-CASC19+anti-miR-410-3p groups were 1.01±0.16，0.96±0.16，0.37±0.13，0.34±0.11，0.35±0.11，respectively，miR-410-3p were 1.00±0.33，1.07±0.34，1.92±0.38，1.88±0.39，1.34±0.37，respectively，and LAMC1 mRNA were 1.00±0.17，1.05±0.17，0.44±0.13，0.41±0.13，0.89±0.15，respectively，with statistically significant differences （F=39.05，P<0.001； F=8.72，P<0.001； F=25.21，P<0.001）. Compared with the NC and sh-NC groups，the expression of CASC19 in the sh-CASC19，sh-CASC19+anti-NC，and sh-CASC19+anti-miR-410-3p groups decreased significantly （all P<0.05），the expression of miR-410-3p in sh-CASC19 group and sh-CASC19+anti-NC group increased significantly，while the expression of LAMC1 mRNA decreased significantly （all P<0.05）. Compared with the sh-CASC19 and sh-CASC19+anti-NC groups，the expression of miR-410-3p in the sh-CASC19+anti-miR-410-3p group decreased significantly，while the expression of LAMC1 increased significantly （all P<0.05）. The EdU-positive cell rates in the five groups were （45.93±5.04）%，（46.07±5.13）%，（19.26±3.25）%，（20.43±3.36）%，（37.85±4.86）%，respectively，the cell viability values were （100.00±0.00）%，（97.26±9.87）%，（46.27±7.12）%，（47.23±7.08）%，and （86.39±9.05）%，respectively，with statistically significant differences （F=54.34，P<0.001； F=76.76，P<0.001）. The scratch healing rates were （47.85±4.90）%，（48.03±4.87）%，（23.97±3.51）%，（23.42±3.26）%，and （39.54±4.12）%，respectively，the numbers of invasion were 114.62±10.98，113.78±11.87，64.53±9.41，65.14±9.04，97.86±10.27，respectively，with statistically significant differences （F=51.26，P<0.001； F=34.81，P<0.001）. The protein expression levels of PCNA were 1.14±0.14，1.17±0.15，0.34±0.10，0.36±0.11，0.93±0.13，respectively，LAMC1 were 1.37±0.15，1.32±0.14，0.59±0.09，0.61±0.09，and 1.18±0.12，respectively，MMP-2 were 0.93±0.13，0.88±0.10，0.23±0.07，0.25±0.08，0.76±0.10，respectively，with statistically significant differences （F=62.32，P<0.001； F=58.94，P<0.001； F=73.41，P<0.001）. Compared with the NC and sh-NC groups，the EdU-positive cell rate，cell viability value，scratch healing rate，number of invasion，and protein expression levels of PCNA，LAMC1，and MMP-2 in the sh-CASC19 and sh-CASC19+anti-NC groups decreased significantly （all P<0.05）. Compared with the sh-CASC19 and sh-CASC19+anti-NC groups，these indices in the sh-CASC19+anti-miR-410-3p group increased significantly （all P<0.05）. Conclusions lncRNA CASC19 may promote the proliferation，migration，and invasion of breast cancer cells by regulating the miR-410-3p/LAMC1 signaling pathway. Figures and Tables | References | Related Articles | Metrics

Research of the mechanism of lncRNA FGD5-AS1/miR-154-5p/WNT5A signaling pathway in regulating proliferation and migration of paclitaxel-resistant gastric cancer cells Qu Zhenjie, Cui Qin 2026, 53 (3):  137-143.  doi: 10.3760/cma.j.cn371439-20250627-00022 Abstract ( 10 )   HTML ( 2 )   PDF (3014KB) ( 1 )   Save Objective To explore the mechanism of the long non-coding RNA （lncRNA） FGD5-AS1/miR-154-5p/WNT5A signaling pathway in regulating the proliferation and migration of paclitaxel （PTX）-resistant gastric cancer cells. Methods The PTX-resistant gastric cancer cell line HGC-27/PTX was divided into sh-NC group （transfected with FGD5-AS1 shRNA negative control），sh-FGD5-AS1 group （transfected with FGD5-AS1 shRNA），sh-NC+PTX group （transfected with FGD5-AS1 shRNA negative control and then incubated with 8 nmol/L PTX for 24 hours），sh-FGD5-AS1+PTX group （transfected with FGD5-AS1 shRNA and then incubated with 8 nmol/L PTX for 24 hours），miR-NC group （transfected with miR-154-5p mimic negative control），miR-154-5p mimic group （transfected with miR-154-5p mimic），si-NC group （transfected with WNT5A siRNA negative control），si-WNT5A group （transfected with WNT5A siRNA），and si-WNT5A+PTX group （transfected with WNT5A siRNA and then incubated with 8 nmol/L PTX for 24 hours）. The relative expression level of FGD5-AS1 was detected by quantitative real-time PCR，the median inhibition concentration （IC50） of PTX on HGC-27/PTX cells was determined by the CCK-8 assay，the apoptosis ability of cells was detected by flow cytometry，and the migration and invasion abilities of cells were assessed using the Transwell chamber assay. The expression of LC3-Ⅱ/LC3-Ⅰ and P62 in cells was detected by Western blotting. The targeting relationships between FGD5-AS1 and miR-154-5p，as well as between miR-154-5p and WNT5A，were verified by dual-luciferase reporter gene assay. Results The IC50 values of HGC-27/PTX cells in the sh-NC group and sh-FGD5-AS1 group were （81.10±1.46），（36.61±2.05） nmol/L，with a statistically significant difference （t=17.45，P<0.001）. The apoptosis rates of HGC-27/PTX cells in the sh-NC group，sh-FGD5-AS1 group，sh-NC+PTX group，and sh-FGD5-AS1+PTX group were （0.24±0.04）%，（6.41±0.90）%，（0.20±0.06）%，and （7.86±1.07）%，respectively，with a statistically significant difference （F=110.40，P<0.001）； there were statistically significant differences between the sh-NC group and sh-FGD5-AS1 group，as well as between the sh-NC+PTX group and sh-FGD5-AS1+PTX group （both P<0.001）. The numbers of cell migration in the four groups of HGC-27/PTX cells were 140.30±15.95，68.00±3.61，124.30±7.02，and 15.00±2.00，respectively，and the numbers of cell invasion were 115.70±6.11，51.33±4.62，114.70±11.24，and 12.33±3.22，respectively，with statistically significant differences （F=122.00，P<0.001； F=161.10，P<0.001）； there were statistically significant differences between the sh-NC group and sh-FGD5-AS1 group，as well as between the sh-NC+PTX group and sh-FGD5-AS1+PTX group （both P<0.001）. The LC3-Ⅱ/LC3-Ⅰ values of the four groups of HGC-27/PTX cells were 1.66±0.11，1.04±0.07，1.64±0.15，and 0.99±0.05，respectively，and the relative expression levels of P62 were 0.24±0.06，0.78±0.08，0.20±0.09，and 1.01±0.08，respectively，with statistically significant differences （F=36.31，P<0.001； F=79.68，P<0.001）； there were statistically significant differences between the sh-NC group and sh-FGD5-AS1 group，as well as between the sh-NC+PTX group and sh-FGD5-AS1+PTX group （both P<0.05）. The dual-luciferase reporter gene assay results showed that，miR-154-5p was a target gene of FGD5-AS1，and WNT5A was a target gene of miR-154-5p. The LC3-Ⅱ/LC3-Ⅰ values of HGC-27/PTX cells in the NC group，si-WNT5A group，si-WNT5A+PTX group were 2.21±0.09，1.96±0.06，and 0.96±0.06，respectively，the relative expression levels of P62 were 0.06±0.02，0.18±0.02，and 0.68±0.04，respectively，with statistically significant differences （F=245.90，P<0.001； F=378.40，P<0.001）； there were statistically significant differences between the si-NC group and the si-WNT5A group，as well as between the si-WNT5A group and the si-WNT5A+PTX group （both P<0.05）. Conclusions The lncRNA FGD5-AS1/miR-154-5p/WNT5A signaling pathway promotes the proliferation and migration of PTX-resistant gastric cancer cells by regulating autophagy. Figures and Tables | References | Related Articles | Metrics

Evaluation of the risk of low-blood-flow BI-RADS category 4 breast lesions with an ultrasound-based XGBoost model He Yuqing, Wu Zizheng, Qi Zhengqin 2026, 53 (3):  144-149.  doi: 10.3760/cma.j.cn371439-20250415-00023 Abstract ( 8 )   HTML ( 2 )   PDF (1489KB) ( 1 )   Save Objective To develop an extreme gradient boosting （XGBoost） model based on clinical and ultrasound features，and to evaluate the model's prediction of the malignancy risk of low-blood-flow （Adler grade 0 -Ⅰ） breast imaging-reporting and data system （BI-RADS） category 4 breast lesions. Methods Clinical and ultrasound data from 317 female patients diagnosed with BI-RADS category 4 breast lesions at First Hospital of Qinhuangdao from June 2023 to December 2024 were retrospectively collected （full-sample，174 benign，143 malignant）. Patients were divided into a training set （n=222，122 benign，100 malignant） and a testing set （n=95，52 benign，43 malignant） using a 7∶3 stratified random sampling method. After excluding patients with high blood flow grades （Adler grade Ⅱ-Ⅲ），166 patients with low blood flow grades were collected and divided 7∶3 into training （n=116，71 benign，45 malignant） and testing （n=50，30 benign，20 malignant） sets. A full-sample XGBoost model for predicting the benign and malignant nature of BI-RADS category 4 breast lesions was constructed based on the well-defined epidemiological risk factors for breast cancer （age，family history of breast cancer，obesity，history of alcohol consumption，and smoking history） and the core assessment indicators for breast lesions recommended by the 2013 ACR BI-RADS classification standard （blood flow grade，maximum lesion diameter，microcalcification，shape，margin，internal echo，posterior echo，and parallel position）. After excluding the blood flow grade variable，a low-blood-flow grade XGBoost model was constructed with the remaining 12 features. The predictive efficacy was evaluated using receiver operator characteristic （ROC） curves； SHapley additive explanation （SHAP） analysis was used to quantify feature contributions； decision curve analysis （DCA） was used to assess accuracy and practicability. Results There were statistically significant differences among patients with benign and malignant breast lesions in the full sample for blood flow grade （χ²=4.99，P=0.026），maximum lesion diameter （χ²=4.47，P=0.034），microcalcifications （χ²=7.10，P=0.009），internal echo （χ²=4.24，P=0.041），and posterior echo （χ²=22.32，P<0.001）. ROC curve analysis showed that，for the full-sample training set，the area under the curve （AUC） of the XGBoost model for predicting benign and malignant BI-RADS category 4 breast lesions was 0.936 （95%CI： 0.902-0.965），with an accuracy of 86.0%，a sensitivity of 88.5%，and a specificity of 83.2%； for the testing set，the AUC was 0.852 （95%CI： 0.787-0.906），with an accuracy of 76.8%，a sensitivity of 78.6%，and a specificity of 75.0%. SHAP analysis showed that，the blood flow grade （Adler gradesⅡ-Ⅲ） had the greatest contribution to the prediction of malignancy risk by the XGBoost model for the full sample，followed by the irregularity of the margin and the absence of parallel position. For the low-blood-flow grade sample training set，the AUC of the XGBoost model for predicting benign and malignant BI-RADS category 4 breast lesions was 0.951 （95%CI： 0.917-0.975），with an accuracy of 86.5%，a sensitivity of 87.9%，and a specificity of 84.8%； for the testing set，the AUC was 0.843 （95%CI： 0.766-0.904），with an accuracy of 79.6%，a sensitivity of 81.5%，and a specificity of 77.8%. Internal validation results showed that the C-index of the XGBoost model for predicting benign and malignant breast lesions was 0.82. SHAP analysis showed that，the posterior echo attenuation had the greatest positive contribution to the prediction of malignancy risk by the XGBoost model for low-blood-flow grade samples，followed by the presence of microcalcification，maximum lesion diameter >2 cm，and inhomogeneous internal echo. DCA showed that this prediction model could provide high clinical net benefit and had certain clinical practicability. Conclusions The XGBoost model based on clinical and ultrasound features effectively evaluates benign and malignant nature of low-blood-flow BI-RADS category 4 breast lesions. Posterior echo attenuation，microcalcification，maximum lesion diameter >2 cm，and inhomogeneous internal echo are key features for predicting malignancy risk in low-blood-flow BI-RADS category 4 breast lesions. Figures and Tables | References | Related Articles | Metrics

Influence of the expression profile characteristics of APO and ILF on the surgical prognosis in patients with locally advanced gastric cancer Ta Na, Han Yun, Long Rui, Hu Jun 2026, 53 (3):  150-156.  doi: 10.3760/cma.j.cn371439-20250823-00024 Abstract ( 5 )   HTML ( 2 )   PDF (897KB) ( 0 )   Save Objective To investigate the influence of the expression profile characteristics of apolipoprotein （APO） and interleukin enhancer binding factor （ILF） on the surgical prognosis in patients with locally advanced gastric cancer. Methods A total of 186 patients with locally advanced gastric cancer who received neoadjuvant chemotherapy （NACT） combined with radical gastrectomy at Karamay Central Hospital of Xinjiang from February 2021 to February 2023 were selected as the research subjects. All patients were followed up for at least 2 years to analyze postoperative survival and tumor progression within 2 years. Differences in general clinical data，tumor pathological features，NACT and surgical characteristics，serum APO level before NACT，and ILF expression in tumor tissues before NACT were compared between patients with poor and good prognosis. Multivariate logistic regression analysis was used to identify influencing factors for surgical prognosis in patients with locally advanced gastric cancer. Receiver operator characteristic （ROC） curve was used to evaluate the efficacy of combined factors in predicting surgical prognosis in patients with locally advanced gastric cancer. Results Within 2 years after surgery，103 patients had tumor recurrence，42 had metastasis，and 62 had related death in 186 patients with locally advanced gastric cancer，with an overall poor prognosis rate of 65.05% （121/186）. The ages of patients with poor and good prognosis were 63 （60，66） and 62 （58，64） years，respectively，with a statistically significant difference （Z=2.14，P=0.032）. The maximum tumor diameter was 5.2 （4.5，5.9） cm in patients with poor prognosis and 4.9 （3.8，5.8） cm in patients with good prognosis，with a statistically significant difference （Z=2.28，P=0.023）. There were statistically significant differences in differentiation degree （χ²=5.47，P=0.019），T stage （χ²=5.41，P=0.020），and N stage （χ²=5.18，P=0.023）. There was a statistically significant difference in NACT efficacy between patients with poor and good prognosis （χ²=6.11，P=0.013）. The number of lymph nodes dissection was 21 （20，22） in patients with poor prognosis and 21 （20，23） in patients with good prognosis，with a statistically significant difference （Z=2.23，P=0.025）. The APOA1 levels before NACT were （893.24±178.12） and （977.13±258.07） mg/L，the APOB levels were （982.00±201.21） and （910.64±153.06） mg/L，the APOC1 levels were （92.88±18.12） and （84.14±20.09） mg/L，and the APOD levels were （76.62±15.89） and （71.34±14.42） mg/L in patients with poor and good prognosis，respectively，all with statistically significant differences （t=2.61，P=0.010； t=2.50，P=0.013； t=3.02，P=0.003； t=2.23，P=0.027）. There were statistically significant differences in the expression of ILF1 and ILF2 in tumor tissues between patients with poor and good prognosis （χ²=6.62，P=0.010； χ²=5.07，P=0.024）. Multivariate analysis showed that，T stage （OR=2.94，95%CI： 1.23-7.01，P=0.015），N stage （OR=2.67，95%CI： 1.14-6.24，P=0.023），NACT efficacy （OR=1.50，95%CI： 1.18-3.33，P=0.026），number of lymph nodes dissection （OR=0.75，95%CI： 0.58-0.96，P=0.024），APOA1 （OR=0.99，95%CI： 0.98-0.99，P=0.042），APOB （OR=1.03，95%CI： 1.00-1.05，P=0.028），APOC1 （OR=1.10，95%CI： 1.01-1.21，P=0.040），ILF1 （OR=2.28，95%CI： 1.04-5.02，P=0.041），and ILF2 （OR=1.86，95%CI： 1.26-3.01，P=0.032） were all independent factors influencing surgical prognosis in patients with locally advanced gastric cancer. The ROC curve analysis showed that，the area under the curve of the combined prediction of the above influencing factors for surgical prognosis in patients with locally advanced gastric cancer was 0.79 （95%CI： 0.72-0.86）. Conclusions APO levels and ILF expression characteristics in tumor tissues are independent influencing factors for surgical prognosis in patients with locally advanced gastric cancer. Combined detection of T stage，N stage，NACT efficacy，number of lymph nodes dissection，APOA1，APOB，APOC1，ILF1，and ILF2 has high predictive efficacy for the surgical prognosis of patients with locally advanced gastric cancer. Figures and Tables | References | Related Articles | Metrics

Analysis of influencing factors and predictive efficacy of biochemical persistence/recurrence after radical resection for high-risk localized prostate cancer Guo Xuetao, Qiao Julong, Shao Hongjiang, Wang Xin, Su Riguge, Liu Lu, Liang Lu 2026, 53 (3):  157-162.  doi: 10.3760/cma.j.cn371439-20250616-00025 Abstract ( 6 )   HTML ( 3 )   PDF (1102KB) ( 0 )   Save Objective To investigate the influencing factors and predictive efficacy of biochemical persistence/recurrence （BPR） after radical resection for high-risk localized prostate cancer （HR-LPCa），and to analyze the clinical performance of a nomogram model constructed based on the influencing factors in predicting postoperative BPR.Methods A total of 172 patients with HR-LPCa who underwent radical resection at Baotou City Central Hospital，Inner Mongolia Autonomous Region from January 2016 to January 2023 were selected as research subjects. Clinicopathological characteristics were compared between patients with and without BPR，and binary logistic regression was used to analyze the influencing factors of postoperative BPR in HR-LPCa patients. A nomogram model was constructed based on the results of multivariate analysis. The receiver operator characteristic （ROC） curve was used to evaluate the predictive efficacy of the model，and the calibration curve was used to assess the accuracy and practicality of the model.Results Among the 172 patients，42 developed biochemical persistence，32 had biochemical recurrence，and 4 progressed to castration resistance. There were statistically significant differences between patients with BPR （n=74） and without BPR （n=98） in baseline prostate-specific antigen density （PSAD） （t=6.93，P<0.001），pathological International Society of Urological Pathology （ISUP） grade （χ²=17.31，P<0.001），and surgical margin status （χ²=29.29，P<0.001）. Multivariate analysis showed that，baseline PSAD （OR=0.01，95%CI： 0.00-0.04，P<0.001），pathological ISUP grade （OR=0.27，95%CI： 0.12-0.61，P=0.002），and surgical margin status （OR=0.18，95%CI： 0.08-0.40，P<0.001） were independent influencing factors for BPR after radical resection in HR-LPCa patients. Based on the multivariate analysis results，a nomogram model was constructed to predict the risk of BPR after radical resection in HR-LPCa patients，logit（P）=4.84-5.99×baseline PSAD-1.32×pathological ISUP grade-1.72×surgical margin status. The ROC curve analysis showed that，the area under the curve （AUC） values of baseline PSAD，pathological ISUP grade，surgical margin status，and the nomogram model for predicting BPR after radical resection in patients with HR-LPCa were 0.76，0.66，0.71，and 0.88，respectively. The AUC of the nomogram model was significantly higher than that of each of the other three indicators alone （Z=-3.62，P<0.001； Z=-4.59，P<0.001； Z=-2.36，P<0.001）. The nomogram model exhibited a C-index of 0.878 and excellent goodness-of-fit （Hosmer-Lemeshow χ²=3.51，P=0.752）. Calibration curves demonstrated that the predicted curve of the nomogram model closely approximated the ideal reference line without significant deviation，indicated good predictive accuracy.Conclusions Baseline PSAD，pathological ISUP grade，and surgical margin status are all independent influencing factors for BPR after radical resection in HR-LPCa patients. The nomogram model constructed based on the above clinicopathological indicators shows good predictive performance. Figures and Tables | References | Related Articles | Metrics

Review

Role of UGT in metabolism of malignant tumors and clinical significance Qiao Jinyang, Li Hui, Feng Qinmei 2026, 53 (3):  163-166.  doi: 10.3760/cma.j.cn371439-20250704-00026 Abstract ( 5 )   HTML ( 2 )   PDF (752KB) ( 0 )   Save Uridine diphosphate-glucuronosyltransferases （UGTs） are key rate-limiting phase Ⅱ enzymes that mediate the glucuronidation of endobiotics and xenobiotics，thereby governing the clearance and signal transduction. UGTs drive oncogenesis，progression and chemoresistance in breast cancer，lung cancer，prostate cancer，and chronic lymphocytic leukemia by regulating estrogen/androgen levels and related receptors，as well as glycolytic and associated signaling pathways. Further exploration of the dual roles of UGTs in various cancer metabolism and the clinical significance will provide novel biomarkers and therapeutic targets for tumor diagnosis，prognosis assessment and precise medication. References | Related Articles | Metrics

Classification，distribution and relationship with tumors of CAF Qing Shuman, Wang Yuanyuan, Yu Shuyang, Li Yingge, Yao Yi 2026, 53 (3):  167-173.  doi: 10.3760/cma.j.cn371439-20250613-00027 Abstract ( 5 )   HTML ( 2 )   PDF (802KB) ( 0 )   Save Cancer-associated fibroblasts （CAFs） are important components in constructing tumor microenvironment and exhibit significant heterogeneity. Currently，more than ten CAFs subtypes have been identified，which can be classified into two major categories： cancer-promoting and cancer-restraining. Cancer-promoting CAFs promotes tumor progression through extracellular matrix remodeling，immune suppression，angiogenesis and metabolic reprogramming. In contrast，cancer-restraining CAFs exerts anti-tumor effects by recruiting CD8+ T cells/natural killer （NK） cells. The spatial distribution of different CAFs subtypes is closely associated with the specific microenvironment of the tumor region，and multiple subtypes can undergo dynamic transformation under specific conditions，inducing tumor treatment resistance and thereby affecting patient prognosis. Targeting the elimination of cancer-promoting CAFs subsets or inducing their transformation into cancer-restraining subtypes is a promising strategy for remodeling the tumor microenvironment，inhibiting tumor progression，and overcoming drug resistance. Figures and Tables | References | Related Articles | Metrics

Research progress of the VGLL1-TEAD4 complex in tumors Shi Haiyan, Ma Yan, Wang Ruoying, Shao Sarula, Guo Ruifang 2026, 53 (3):  174-177.  doi: 10.3760/cma.j.cn371439-20250719-00028 Abstract ( 4 )   HTML ( 1 )   PDF (777KB) ( 0 )   Save VGLL1 is overexpressed in various aggressive tumors. It primarily forms the VGLL1-TEAD4 complex by binding to TEAD4，which regulates downstream target genes to participate in processes such as tumor proliferation，invasion，metastasis，and immune evasion. This paper explores the therapeutic strategies of small-molecule inhibitors and peptide-based drugs targeting the binding interface of this complex，and analyzes the clinical translational potential of the targeted VGLL1-TEAD4 complex in the treatment of solid tumors such as gastric cancer and breast cancer，with the aim of providing a theoretical foundation for understanding oncogenic mechanisms and developing targeted therapies. References | Related Articles | Metrics

Advances in cancer chemotherapy in the era of precision medicine Zhang Baihong, Yue Hongyun 2026, 53 (3):  178-181.  doi: 10.3760/cma.j.cn371439-20250719-00029 Abstract ( 4 )   HTML ( 1 )   PDF (744KB) ( 0 )   Save Chemotherapy remains the cornerstone of systemic treatment for tumors. In the era of precision medicine，gene monitoring and model prediction can monitor the response and toxicity of chemotherapy drugs and guide clinicians in choosing appropriate treatment plans. Nanotechnology delivery can reduce the toxicity and treatment resistance of chemotherapy drugs. Antibody conjugation can directly target chemotherapy drugs to tumor cells with precision，thus jointly promoting precise chemotherapy for tumors. Artificial intelligence and machine learning will further drive the development of precise chemotherapy for tumors. References | Related Articles | Metrics

Immune remodeling strategies and clinical progress of the transformation of gastric cold tumors into hot tumors Ma Zhuaxiji, Min Xiyun, Guan Quanlin 2026, 53 (3):  182-186.  doi: 10.3760/cma.j.cn371439-20250919-00030 Abstract ( 6 )   HTML ( 1 )   PDF (769KB) ( 0 )   Save The immune evasion of cold tumors in gastric cancer caused by insufficient T-cell infiltration hinders the widespread application of immunotherapy in gastric cancer. Clarifying the differences in biological characteristics between cold and hot tumors，as well as the association between gastric cancer molecular subtypes and immune phenotypes，is helpful for understanding the core mechanisms of the transformation from cold tumors into hot tumors，including enhancing antigen presentation，promoting immune cell infiltration and activation，and reversing the immunosuppressive microenvironment. In terms of clinical translation，relevant approaches include immunotherapy，combination therapy，and novel immunotherapies. Additionally，microbiome regulation and exercise may serve as new directions to enhance therapeutic efficacy. In the future，it will be necessary to develop combination strategies based on multi-omics stratification to achieve precise transformation of cold tumors，overcome drug resistance，and improve patient prognosis. References | Related Articles | Metrics

Research progress of ferroptosis in cervical cancer Yang Qing, He Xiyan, Sun Xiaotong 2026, 53 (3):  187-192.  doi: 10.3760/cma.j.cn371439-20250712-00031 Abstract ( 3 )   HTML ( 1 )   PDF (784KB) ( 0 )   Save Cervical cancer remains a common malignancy of the female reproductive system. Postoperative metastasis，recurrence，and resistance to radiotherapy and chemotherapy pose formidable challenges. Ferroptosis，an iron-dependent form of programmed cell death，has demonstrated potential in selectively inducing cervical cancer cell death by targeting relevant molecules and signaling pathways. The development of small molecule drugs and natural active components targeting ferroptosis to reverse radiotherapy and chemotherapy resistance，as well as the construction of ferroptosis biomarker prognostic models and the exploration of combined strategies with immunotherapy，provide more possibilities for precise treatment of breast cancer. A detailed elucidation of the mechanism of ferroptosis in cervical cancer and the significance of targeting ferroptosis for cervical cancer treatment can provide certain theoretical support for the diagnosis and treatment of cervical cancer. References | Related Articles | Metrics