Research progress of the VGLL1-TEAD4 complex in tumors

doi:10.3760/cma.j.cn371439-20250719-00028

Abstract

Abstract:

VGLL1 is overexpressed in various aggressive tumors. It primarily forms the VGLL1-TEAD4 complex by binding to TEAD4，which regulates downstream target genes to participate in processes such as tumor proliferation，invasion，metastasis，and immune evasion. This paper explores the therapeutic strategies of small-molecule inhibitors and peptide-based drugs targeting the binding interface of this complex，and analyzes the clinical translational potential of the targeted VGLL1-TEAD4 complex in the treatment of solid tumors such as gastric cancer and breast cancer，with the aim of providing a theoretical foundation for understanding oncogenic mechanisms and developing targeted therapies.

Key words: Neoplasms, Molecular targeted therapy, VGLL1-TEAD4 complex

Shi Haiyan, Ma Yan, Wang Ruoying, Shao Sarula, Guo Ruifang. Research progress of the VGLL1-TEAD4 complex in tumors[J]. Journal of International Oncology, 2026, 53(3): 174-177.

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