Regulatory mechanisms， clinical significance and targeted therapeutic strategies of the immune checkpoint VISTA in tumors

doi:10.3760/cma.j.cn371439-20250605-00133

Abstract

Abstract:

The V-domain immunoglobulin suppressor of T cell activation （VISTA） is a novel immune checkpoint protein belonging to the B7 family. VISTA is highly expressed in various malignant tumors， and its expression level is closely associated with tumor clinical characteristics and patient prognosis. By binding to its ligand in the tumor microenvironment， VISTA mediates multiple immune escape mechanisms， promoting the progression of virous malignancies and immune resistance， making it a novel target for tumor immunotherapy. Currently， several VISTA inhibitors have entered clinical trial phases， including monotherapy with VISTA inhibitors and combination strategies with other immunomodulatory agents. These developments collectively demonstrate that VISTA is a next-generation immunotherapy target with significant clinical potential.

Key words: Neoplasms, Immune checkpoint proteins, Tumor microenvironment, Therapy, VISTA

Wang Jing, Li Baozhong. Regulatory mechanisms， clinical significance and targeted therapeutic strategies of the immune checkpoint VISTA in tumors[J]. Journal of International Oncology, 2025, 52(12): 782-786.

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