Research progress of avermectins in anti-tumor

doi:10.3760/cma.j.cn371439-20220321-00067

Abstract

Abstract:

Avermectins can affect biological processes of multiple tumor, including tumor cell proliferation and metastasis, cell cycle arrest, induction of apoptosis and autophagy, regulation of tumor microenvironment and tumor stem cells. Avermectins can be administered alone or combined with chemotherapeutic drugs to reverse multidrug resistance. To further explore the anti-tumor mechanism of avermectins will provide reliable experimental and theoretical guidance for future clinical application.

Key words: Antineoplastic agents, Molecular mechanisms of pharmacological action, Avermectins

Wang Liwei, Liang Hongsheng, Du Songlin, Chen Zhihao, Wang Qing, Gao Aili. Research progress of avermectins in anti-tumor[J]. Journal of International Oncology, 2022, 49(6): 353-356.

References 33

[1]	Du Y, Shao Z, Xu Q, et al. Azobenzene-avermectin B1a derivatives for optical modulation of insect behaviors[J]. J Agric Food Chem, 2021, 69(51): 15530-15537. DOI: 10.1021/acs.jafc.1c05036. doi: 10.1021/acs.jafc.1c05036
[2]	de Melo GD, Lazarini F, Larrous F, et al. Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin[J]. EMBO Mol Med, 2021, 13(8): e14122. DOI: 10.15252/emmm.202114122. doi: 10.15252/emmm.202114122
[3]	Popp M, Stegemann M, Metzendorf MI, et al. Ivermectin for preventing and treating COVID-19[J]. Cochrane Database Syst Rev, 2021, 7(7): CD015017. DOI: 10.1002/14651858.CD015017.pub2. doi: 10.1002/14651858.CD015017.pub2
[4]	Diao L, Tang N, Zhang C, et al. Avermectin induced DNA damage to the apoptosis and autophagy in human lung epithelial A549 cells[J]. Ecotoxicol Environ Saf, 2021, 215: 112129. DOI: 10.1016/j.ecoenv.2021.112129. doi: 10.1016/j.ecoenv.2021.112129
[5]	Liu Y, Fang S, Sun Q, et al. Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress[J]. Biochem Biophys Res Commun, 2016, 480(3): 415-421. DOI: 10.1016/j.bbrc.2016.10.064. doi: 10.1016/j.bbrc.2016.10.064
[6]	Zhang X, Qin T, Zhu Z, et al. Ivermectin augments the in vitro and in vivo efficacy of cisplatin in epithelial ovarian cancer by suppressing Akt/mTOR signaling[J]. Am J Med Sci, 2020, 359(2): 123-129. DOI: 10.1016/j.amjms.2019.11.001. doi: 10.1016/j.amjms.2019.11.001
[7]	罗丹, 罗亮, 杨志军, 等. 阿维菌素对胶质母细胞瘤U251细胞增殖、凋亡的影响及其机制探讨[J]. 山东医药, 2017, 57(27): 31-33. DOI: 10.3969/j.issn.1002-266X.2017.27.008. doi: 10.3969/j.issn.1002-266X.2017.27.008
[8]	张阳. 阿维菌素的细胞毒性及分子机理研究[D]. 上海: 华东理工大学, 2017.
[9]	Zhang Y, Wu J, Xu W, et al. Cytotoxic effects of Avermectin on human HepG2 cells in vitro bioassays[J]. Environ Pollut, 2017, 220(Pt B): 1127-1137. DOI: 10.1016/j.envpol.2016.11.022. doi: 10.1016/j.envpol.2016.11.022
[10]	Zhang X, Zhang G, Zhai W, et al. Inhibition of TMEM16A Ca²⁺-activated Cl^- channels by avermectins is essential for their anticancer effects[J]. Pharmacol Res, 2020, 156: 104763. DOI: 10.1016/j.phrs.2020.104763. doi: 10.1016/j.phrs.2020.104763
[11]	Zhu S, Zhou J, Zhou Z, et al. Abamectin induces apoptosis and autophagy by inhibiting reactive oxygen species-mediated PI3K/AKT signaling in MGC803 cells[J]. J Biochem Mol Toxicol, 2019, 33(7): e22336. DOI: 10.1002/jbt.22336. doi: 10.1002/jbt.22336
[12]	Liang Y, Dong B, Pang N, et al. Abamectin induces cytotoxicity via the ROS, JNK, and ATM/ATR pathways[J]. Environ Sci Pollut Res Int, 2020, 27(12): 13726-13734. DOI: 10.1007/s11356-019-06869-2. doi: 10.1007/s11356-019-06869-2
[13]	Dominguez-Gomez G, Chavez-Blanco A, Medina-Franco JL, et al. Ivermectin as an inhibitor of cancer stem‑like cells[J]. Mol Med Rep, 2018, 17(2): 3397-3403. DOI: 10.3892/mmr.2017.8231. doi: 10.3892/mmr.2017.8231 pmid: 29257278
[14]	Zhang P, Zhang Y, Liu K, et al. Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway[J]. Cell Prolif, 2019, 52(2): e12543. DOI: 10.1111/cpr.12543. doi: 10.1111/cpr.12543
[15]	Song D, Liang H, Qu B, et al. Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo[J]. J Cell Biochem, 2019, 120(1): 622-633. DOI: 10.1002/jcb.27420. doi: 10.1002/jcb.27420
[16]	Chen L, Bi S, Wei Q, et al. Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma[J]. J Cell Mol Med, 2020, 24(9): 5387-5401. DOI: 10.1111/jcmm.15195. doi: 10.1111/jcmm.15195
[17]	汤月良, 邓冠群. 伊维菌素对奥沙利铂抗结肠癌耐药细胞的增效作用及其机制[J]. 解放军医学杂志, 2021, 46(6): 563-573. DOI: 10.11855/j.issn.0577-7402.2021.06.06. doi: 10.11855/j.issn.0577-7402.2021.06.06
[18]	Jiang L, Wang P, Sun YJ, et al. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway[J]. J Exp Clin Cancer Res, 2019, 38(1): 265. DOI: 10.1186/s13046-019-1251-7. doi: 10.1186/s13046-019-1251-7
[19]	Juarez M, Schcolnik-Cabrera A, Dueñas-Gonzalez A. The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug[J]. Am J Cancer Res, 2018, 8(2): 317-331. pmid: 29511601
[20]	Draganov D, Han Z, Rana A, et al. Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer[J]. NPJ Breast Cancer, 2021, 7(1): 22. DOI: 10.1038/s41523-021-00229-5. doi: 10.1038/s41523-021-00229-5 pmid: 33654071
[21]	Wang K, Gao W, Dou Q, et al. Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer[J]. Autophagy, 2016, 12(12): 2498-2499. DOI: 10.1080/15548627.2016.1231494. doi: 10.1080/15548627.2016.1231494 pmid: 27657889
[22]	Dou Q, Chen HN, Wang K, et al. Ivermectin induces cytostatic autophagy by blocking the PAK1/Akt axis in breast cancer[J]. Cancer Res, 2016, 76(15): 4457-4469. DOI: 10.1158/0008-5472.CAN-15-2887. doi: 10.1158/0008-5472.CAN-15-2887
[23]	Gallardo F, Mariamé B, Gence R, et al. Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth[J]. Drug Des Devel Ther, 2018, 12: 2805-2814. DOI: 10.2147/DDDT.S172538. doi: 10.2147/DDDT.S172538
[24]	Taciak B, Pruszynska I, Kiraga L, et al. Wnt signaling pathway in development and cancer[J]. J Physiol Pharmacol, 2018, 69(2): 185-196. DOI: 10.26402/jpp.2018.2.07. doi: 10.26402/jpp.2018.2.07
[25]	Seth C, Mas C, Conod A, et al. Long-lasting WNT-TCF response blocking and epigenetic modifying activities of withanolide F in human cancer cells[J]. PLoS One, 2016, 11(12): e0168170. DOI: 10.1371/journal.pone.0168170. doi: 10.1371/journal.pone.0168170
[26]	Chen C, Liang H, Qin R, et al. Doramectin inhibits glioblastoma cell survival via regulation of autophagy in vitro and in vivo[J]. Int J Oncol, 2022, 60(3): 29. DOI: 10.3892/ijo.2022.5319. doi: 10.3892/ijo.2022.5319
[27]	李新, 王晓兴, 王丽薇, 等. 多拉菌素通过线粒体信号通路诱导食管癌细胞凋亡[J]. 中国医院药学杂志, 2021, 41(14): 1410-1416. DOI: 10.13286/j.1001-5213.2021.14.07. doi: 10.13286/j.1001-5213.2021.14.07
[28]	高爱丽, 梁洪生, 史国军, 等. 多拉菌素对人乳腺癌细胞阿霉素多药耐药性的体外逆转作用[J]. 中国医院药学杂志, 2014, 34(4): 266-269. DOI: 10.13286/j.cnki.chinhosppharmacyj.2014.04.05. doi: 10.13286/j.cnki.chinhosppharmacyj.2014.04.05
[29]	韩胜楠, 郭文洁. 塞拉菌素对猫耳螨病的诊治[J]. 今日畜牧兽医, 2022, 38(2): 86. DOI: 10.3969/j.issn.1673-4092.2022.02.066. doi: 10.3969/j.issn.1673-4092.2022.02.066
[30]	Ezquerra-Aznárez JM, Degiacomi G, Gašparovič H, et al. The veterinary Anti-parasitic selamectin is a novel inhibitor of the Mycobacterium tuberculosis DprE1 enzyme[J]. Int J Mol Sci, 2022, 23(2): 771. DOI: 10.3390/ijms23020771. doi: 10.3390/ijms23020771
[31]	Yun X, Rao W, Xiao C, et al. Apoptosis of leukemia K562 and Molt-4 cells induced by emamectin benzoate involving mitochondrial membrane potential loss and intracellular Ca²⁺ modulation[J]. Environ Toxicol Pharmacol, 2017, 52: 280-287. DOI: 10.1016/j.etap.2017.04.013. doi: 10.1016/j.etap.2017.04.013
[32]	Chen Y, Liu X, Yan D, et al. Exposure to emamectin benzoate confers cytotoxic effects on human molt-4 T-cells and possible ameliorative role of vitamin E and dithiothreitol[J]. Drug Chem Toxicol, 2022: 1-10. Inpress. DOI: 10.1080/01480545.2022.2044350. doi: 10.1080/01480545.2022.2044350
[33]	Samy ALPA, Bakthavachalam V, Vudutha M, et al. Eprinomectin, a novel semi-synthetic macrocylic lactone is cytotoxic to PC3 metastatic prostate cancer cells via inducing apoptosis[J]. Toxicol Appl Pharmacol, 2020, 401: 115071. DOI: 10.1016/j.taap.2020.115071. doi: 10.1016/j.taap.2020.115071