Abstract: Cancer stem cells have selfrenewal and multilineage differentiation potentials, which play important roles in tumorigenesis, metastasis, recurrence and resistance to chemical therapy and radiotherapy, and so on. It is the hotspot of tumor research recently. Aptamer is a small molecular oligonucleotide with high targeting ability and affinity, which is a new type of nucleic acid in the diagnosis and treatment of cancer. Now more and more research is being done on the aptamer is applied in the diagnosis and treatment of cancer stem cells, which provides a new research tool for the diagnosis and treatment of cancer stem cells.

Key words: Neoplastic stem cells, SELEX aptamer technique, Neoplasms