Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (8): 676-678.doi: 10.3760/cma.j.issn.1673422X.2017.09.008

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Research advances of LINE-1 in tumor

Tang Meiling, Wu Jianxin, Chang Huibo   

  1. Department of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China
  • Online:2017-09-08 Published:2017-10-31
  • Contact: Chang Huibo E-mail:huibochang2012@163.com
  • Supported by:

    National Natural Science Foundation of China (81301773); Capital Institute of Pediatrics Directional Guidance Fund (FX-2016-3)

Abstract: The abnormality of long interspersed nuclear element1 (LINE1) is closely related to the occurrence and development of tumor. Overexpression of LINE1 can promote cell proliferation and affect the prognosis and metastasis of tumor. The retrotransposition and methylation status of LINE1 have potential application value in clinical diagnosis, prognosis, disease monitoring and treatment.

Key words: Neoplasms, Methylation, Retroelements, Long interspersed nuclear element-1