Expression and role of Golgi phosphoprotein 3 in cancer

doi:10.3760/cma.j.issn.1673422X.2017.01.007

Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (1): 27-30.doi: 10.3760/cma.j.issn.1673422X.2017.01.007

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Expression and role of Golgi phosphoprotein 3 in cancer

Lin Yanping, Li Hong, Shen Lida

First Department of Medical Oncology, Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, China

Online:2017-01-08 Published:2016-12-07
Contact: Shen Lida, Email: shenlida2560@qq.com E-mail:shenlida2560@qq.com
Supported by:
Health Science and Technology Planning Project of Yunnan Province (2016NS110)

Abstract

Abstract: Golgi phosphoprotein 3 (GOLPH3) is closely related to the development and prognosis of cancer, such as nonsmall cell lung cancer, breast cancer, gastric cancer, esophageal cancer, colorectal cancer, etc. The mainly tumor pathogenisis related GOLPH3 includes modulating the response to DNA damage, vesicle trafficking, mTOR signaling pathway, mitochondrial functions, cytokinesis and Golgi vesicular malignant secretion, and then promoting cell proliferation, invasion and metastasis. GOLPH3 is expected to be a new target for cancer therapy, which may become an important biomarker for the diagnosis, treatment and prognosis of cancer.

Key words: Neoplasms, Golgi phosphoprotein 3

Lin Yanping, Li Hong, Shen Lida. Expression and role of Golgi phosphoprotein 3 in cancer[J]. Journal of International Oncology, 2017, 44(1): 27-30.

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Expression and role of Golgi phosphoprotein 3 in cancer

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