Abstract: Long noncoding RNA (lncRNA) is a class of RNA molecules that longer than 200 nucleotides. lncRNA is lack of functional open reading frames and has no protein coding ability. Recently, accumulating evidences indicate that lncRNA plays active roles in tumor carcinogenesis and progression. The aberrant expression of lncRNA is significantly correlated with the growth, metastasis, and therapyresistance of digestive system tumors. Thus, lncRNA may be served as new targets for the diagnosis, treatment, and prognosis of patients with digestive system tumors.

Key words: Digestive system neoplasms, Tumor markers, biological, Long noncoding RNA