ABCA1: a new therapeutic target of tumor

doi:10.3760/cma.j.issn.1673422X.2016.12.010

Abstract

Abstract: ATPbinding cassette transporter A1 is one of the important members of the ABC transporter protein family, which plays a very crucial role in cholesterol reverse transport, cholesterol metabolism and the regulation of highdensity lipoprotein (HDL) metabolism. Mutation of ABCA1 gene could induce Trangier disease and familial deficiency of HDL. Recent studies have pointed out that ABCA1 could have anticancer activity through cholesterol efflux, which will become a promising new therapeutic target of tumor.

Key words: Neoplasms, Cholesterol, ATPbinding cassette transporter A1

XIONG Ting, HUANG Xue-Long, LU Kai-Qiang, LIU Xiao-Wang, XIE Wei-Quan, CHEN Hong-Fei, TU Jian. ABCA1: a new therapeutic target of tumor[J]. Journal of International Oncology, 2016, 43(12): 921-923.

References

［1］ Kaneko T, Kanno C, IchikawaTomikawa N, et al. Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via upregulation of ABCA1 expression［J］. Oncotarget, 2015, 6(32): 3334533357. DOI: 10.18632/oncotarget.5428. ［2］ Smith B, Land H. Anticancer activity of the cholesterol exporter ABCA1 gene［J］. Cell Rep, 2012, 2(3): 580590. DOI: 10.1016/j.celrep.2012.08.011. ［3］ Chou JL, Huang RL, Shay J, et al. Hypermethylation of the TGFβ target, ABCA1 is associated with poor prognosis in ovarian cancer patients［J］. Clin Epigenetics, 2015, 7(1): 1. DOI: 10.1186/s1314801400362. ［4］ Zhao W, Prijic S, Urban BC, et al. Candidate antimetastasis drugs suppress the metastatic capacity of breast cancer cells by reducing membrane fluidity［J］. Cancer Res, 2016, 76(7): 20372049. DOI: 10.1158/00085472.CAN151970. ［5］ Vargas T, MorenoRubio J, Herranz J, et al. ColoLipidGene: signature of lipid metabolismrelated genes to predict prognosis in stageⅡ colon cancer patients［J］. Oncotarget, 2015, 6(9): 73487363. DOI: 10.18632/oncotarget.3130. ［6］ Lv J, Fu Z, Shi M, et al. Systematic analysis of gene expression pattern in hasmiR760 overexpressed resistance of the MCF7 human breast cancer cell to doxorubicin［J］. Biomed Pharmacother, 2015, 69(69): 162169. DOI: 10.1016/j.biopha.2014.11.028. ［7］ Prochazka L, Koudelka S, Dong LF, et al. Mitochondrial targeting overcomes ABCA1dependent resistance of lung carcinoma to αtocopheryl succinate［J］. Apoptosis, 2013, 18(3): 286299. DOI: 10.1007/s1049501207951. ［8］ Tang C, Houston BA, Storey C, et al. Both STAT3 activation and cholesterol efflux contribute to the antiinflammatory effect of apoAI/ABCA1 interaction in macrophages［J］. J Lipid Res, 2016, 57(5): 848857. DOI: 10.1194/jlr.M065797. ［9］ Ramírez CM, Lin CS, Abdelmohsen K, et al. RNA binding protein HuR regulates the expression of ABCA1［J］. J Lipid Res, 2014, 55(6): 10661076. DOI: 10.1194/jlr.M044925. ［10］ Jan A, Karasinska JM, Kang MH, et al. Direct intracerebral delivery of a miR33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression［J］. Neurosci Lett, 2015, 598(598): 6672. DOI: 10.1016/j.neulet.2015.05.007. ［11］ Kaneko T, Kanno C, IchikawaTomikawa N, et al. Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via upregulation of ABCA1 expression［J］. Oncotarget, 2015, 6(32): 3334533357. DOI: 10.18632/oncotarget.5428. ［12］ Dufour J, Pommier A, Alves G, et al. Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell［J］. PLoS One, 2013, 8(3): e58876. DOI: 10.1371/journal.pone.0058876. ［13］ Yang CM, Lu YL, Chen HY, et al. Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgenindependent prostate cancer cells via the PPARγLXRαABCA1 pathway［J］. J Nutr Biochem, 2012, 23(9): 11551162. DOI: 10.1016/j.jnutbio.2011.06.009. ［14］ Huang CX, Zhang YL, Wang JF, et al. MCP1 impacts RCT by repressing ABCA1, ABCG1, and SRBI through PI3K/Akt posttranslational regulation in HepG2 cells［J］. J Lipid Res, 2013, 54(5): 12311240. DOI: 10.1194/jlr.M032482. ［15］ Mo W, Zhang J, Li X, et al. Identification of novel ARtargeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer［J］. PLoS One, 2013, 8(2): e56592. DOI: 10.1371/journal.pone.0056592. ［16］ Leon CG, Locke JA, Adomat HH, et al. Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castrationresistant prostate cancer in a mouse xenograft model［J］. Prostate, 2010, 70(4): 390400. DOI: 10.1002/pros.21072. ［17］ Mulay V, Wood P, Manetsch M, et al. Inhibition of mitogenactivated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells［J］. PLoS One, 2013, 8(4): e62667. DOI: 10.1371/journal.pone.0062667. ［18］ Jones RJ, Gu D, Bjorklund CC, et al. The novel anticancer agent JNJ26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1［J］. J Pharmacol Exp Ther, 2013, 346(3): 381392. DOI: 10.1124/jpet.113.204958. ［19］ Pommier AJ. Alves G, Viennois E, et al. Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apotosis of prostate cancer cells［J］. Oncogene, 2012, 29: 27122723. DOI: 10.1038/onc, 2010 (29): 27122723. ［20］ Sun DX, Liao GJ, Liu KG, et al. Endosialinexpressing bone sarcoma stemlike cells are highly tumorinitiating and invasive［J］. Mol Med Rep, 2015, 12(4): 56655670. DOI: 10.3892/mmr.2015.4218. ［21］ Bloise E, OrtigaCarvalho TM, Reis FM, et al. ATPbinding cassette transporters in reproduction: a new frontier［J］. Hum Reprod Update, 2016, 22(2): 164181. DOI: 10.1093/humupd/dmv049.

[1]	Liu Na, Kou Jieli, Yang Feng, Liu Taotao, Li Danping, Han Junrui, Yang Lizhou. Clinical value of serum miR-106b-5p and miR-760 combined with low-dose spiral CT in the diagnosis of early lung cancer [J]. Journal of International Oncology, 2024, 51(6): 321-325.
[2]	Yang Mi, Bie Jun, Zhang Jiayong, Deng Jiaxiu, Tang Zuge, Lu Jun. Analysis of the efficacy and prognosis of neoadjuvant therapy for locally advanced resectable esophageal cancer [J]. Journal of International Oncology, 2024, 51(6): 332-337.
[3]	Yuan Jian, Huang Yanhua. Diagnostic value of Hp-IgG antibody combined with serum DKK1 and sB7-H3 in early gastric cancer [J]. Journal of International Oncology, 2024, 51(6): 338-343.
[4]	Chen Hongjian, Zhang Suqing. Study on the relationship between serum miR-24-3p， H2AFX and clinical pathological features and postoperative recurrence in liver cancer patients [J]. Journal of International Oncology, 2024, 51(6): 344-349.
[5]	Guo Zehao, Zhang Junwang. Role of PFDN and its subunits in tumorigenesis and tumor development [J]. Journal of International Oncology, 2024, 51(6): 350-353.
[6]	Zhang Baihong, Yue Hongyun. Advances in anti-tumor drugs with new mechanisms of action [J]. Journal of International Oncology, 2024, 51(6): 354-358.
[7]	Xu Fenglin, Wu Gang. Research progress of EBV in tumor immune microenvironment and immunotherapy of nasopharyngeal carcinoma [J]. Journal of International Oncology, 2024, 51(6): 359-363.
[8]	Wang Ying, Liu Nan, Guo Bing. Advances of antibody-drug conjugate in the therapy of metastatic breast cancer [J]. Journal of International Oncology, 2024, 51(6): 364-369.
[9]	Zhang Rui, Chu Yanliu. Research progress of colorectal cancer risk assessment models based on FIT and gut microbiota [J]. Journal of International Oncology, 2024, 51(6): 370-375.
[10]	Gao Fan, Wang Ping, Du Chao, Chu Yanliu. Research progress on intestinal flora and non-surgical treatment of the colorectal cancer [J]. Journal of International Oncology, 2024, 51(6): 376-381.
[11]	Liu Jing, Liu Qin, Huang Mei. Prognostic model construction of lung infection in patients with chemoradiotherapy for esophageal cancer based on SMOTE algorithm [J]. Journal of International Oncology, 2024, 51(5): 267-273.
[12]	Yang Lin, Lu Ning, Wen Hua, Zhang Mingxin, Zhu Lin. Study on the clinical relationship between inflammatory burden index and gastric cancer [J]. Journal of International Oncology, 2024, 51(5): 274-279.
[13]	Wang Junyi, Hong Kaibin, Ji Rongjia, Chen Dachao. Effect of cancer nodules on liver metastases after radical resection of colorectal cancer [J]. Journal of International Oncology, 2024, 51(5): 280-285.
[14]	Zhang Ningning, Yang Zhe, Tan Limei, Li Zhenning, Wang Di, Wei Yongzhi. Diagnostic value of cervical cell DNA ploidy analysis combined with B7-H4 and PKCδ for cervical cancer [J]. Journal of International Oncology, 2024, 51(5): 286-291.
[15]	Fu Yi, Ma Chenying, Zhang Lu, Zhou Juying. Research progress of habitat analysis in radiomics of malignant tumors [J]. Journal of International Oncology, 2024, 51(5): 292-297.