Abstract: Radiofrequency ablation therapy not only causes the necrosis of localized tumor cells, but also produces immunogenic tumor associated antigens and a large number of inflammatory cytokines and a variety of immunogenic mediums, which promotes the local infiltration and activation of immune cells and stimulates the immune system to produce certain antitumor effect. But the intensity of antitumor effect is feeble and is insufficient to inhibit the growth of tumor cells. Radiofrequency ablation therapy combined with special immunotherapies, such as immune stimulants, adoptive immunity cells therapy, dendritic cell vaccines, monoclonal antibodies and so on, can maximize the clinical benefit, which is a good pattern about tumor comprehensive treatment containing immunotherapy.

Key words: Neoplasms, Immune system, Cytokines, Lymphocytes, Radiofrequency ablation