Glycolysis abnormality in neoplasm cells and the targeted therapy

Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (10): 726-728.

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Glycolysis abnormality in neoplasm cells and the targeted therapy

PANG Yu-Yang, WANG Ting, CHEN Fang-Yuan

Department of Hematology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Online:2012-10-31 Published:2012-10-31
Contact: CHEN Fang-yuan， E-mail: chenfy04@yahoo.com.cn E-mail:chenfy04@yahoo.com.cn

Abstract

Abstract: Cancer cells display a decreased mitochondrial respiration along with an abnormal activation of glycolysis to satisfy the demand of the malignant growth even in the presence of oxygen. This phenomenon may be caused by mitochondrial dysfunction, hypoxia of microenvironment and the abnormal activation of upstream regulators of glycolysis pathway. Treatment targeted at the glycolysis pathway and its upstream regulators may provide a new therapeutic strategy of cancer.

Key words: Neoplasms, Glycolysis, Therapies

PANG Yu-Yang, WANG Ting, CHEN Fang-Yuan. Glycolysis abnormality in neoplasm cells and the targeted therapy[J]. Journal of International Oncology, 2012, 39(10): 726-728.

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Glycolysis abnormality in neoplasm cells and the targeted therapy

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