Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (10): 723-725.

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Amplified in breast cancer 3 gene in tumors

BI  Lei, ZHANG  Hao   

  1. Cancer Research Center of Shantou University Medical College, Shantou 515041, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: ZHANG Hao, E-mail: haolabcancercenter@gmail.com E-mail:haolabcancercenter@gmail.com

Abstract: Amplified in breast cancer 3(AIB3) is a newly discovered pleiotropic nuclear receptor coactivator. AIB3 regulates cell proliferation, growth, migration and apoptosis by interacting with many nuclear receptors. At the mean time, some reports show that AIB3 interacts with variety of transcription factors, which indicates AIB3 may play an important role in cancer occurrence and progression.

Key words: Neoplasms, Nuclear receptor coactivator, Cell proliferation