Abstract: 【Abstract】ObjectiveTo study the relationships between androgen receptor (AR) expression and the clinicopathological features and prognosis of young patients (age≤35 years) with earlyonset breast cancer in Xinjiang. MethodsOne hundred and fortyfive young patients (age≤35 years) with invasive breast cancer who underwent surgery in Affiliated Cancer Hospital of of Xinjiang Medical University from January 2010 to December 2012 were collected. The expressions of AR in 145 patiens with earlyonset breast cancer were detected by immunohistochemical method. The relationships between AR expression and the clinicopathological features and prognosis of patients with earlyonset breast cancer were retrospective analysed. ResultsThe positive rate of AR expression of patients with earlyonset breast cancer in Xinjiang was 69.0% (100/145). Single factor analysis showed that AR expression was related with neurovascular invasion (χ2=5.309, P=0.021) and lymph node metastasis (χ2=6.073, P=0.014), but it was not related with ethnicity (χ2=0.097, P=0.755), age (χ2=0.045, P=0.831), feeding history (χ2=0.066, P=0.797), family history of cancer (P=0.556), histological grade (P=0.469), tumor size (χ2=1.006, P=0.605) and clinical stage (χ2=4.381, P=0.223). The median followup time was 47 months. There was no significant difference between AR expression and diseasefree survival of patients with earlyonset breast cancer (χ2=1.972, P=0.160). ConclusionEarlyonset breast cancer patients with AR positive are more likely to appear lymph node metastasis and neurovascular invasion than the patients with AR negative, which has certain guidance means for the treatment of earlyonset breast cancer with lymph node metastasis positive.

Key words: Bresat neoplasms, Neoplasm staging, Receptors, estrogen, Lymph node metastasis